| Gene Symbol |
S1PR1
|
| Entrez Gene |
1901
|
| Alt Symbol |
CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sphingosine-1-phosphate receptor 1
|
| Other Description |
S1P receptor 1|S1P receptor Edg-1|endothelial differentiation G-protein coupled receptor 1|endothelial differentiation, sphingolipid G-protein-coupled receptor, 1|sphingosine 1-phosphate receptor 1|sphingosine 1-phosphate receptor EDG1|sphingosine 1-phosphate receptor Edg-1
|
| Swissprots |
Q9NYN8 Q9BYY4 D3DT66 P21453
|
| Accessions |
AAK01993 EAW72927 EAW72928 P21453 AF022137 AAC51905 AF233365 AAF43420 AK297005 BAG59541 AK312493 BAG35395 BC018650 AAH18650 BI598518 BU677564 CF994197 CR541786 CAG46585 CR542269 CAG47065 CR977007 DB132417 DB572979 M31210 AAA52336 XM_006710399 XP_006710462 NM_001400 NP_001391
|
| Function |
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl- 2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.
|
| Tissue Specificity |
Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
|
| Top Pathways |
Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction
|
![Western Blot: EDG1 Overexpression Lysate (Adult Normal) [NBP2-04197] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for EDG1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8949_EDG1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04197-img0001.jpg)