CACNA2D2

Gene Symbol CACNA2D2
Entrez Gene 9254
Alt Symbol CACNA2D
Species Human
Gene Type protein-coding
Description calcium channel, voltage-dependent, alpha 2/delta subunit 2
Other Description alpha 2 delta calcium channel subunit|gene 26|voltage-dependent calcium channel subunit alpha-2/delta-2|voltage-gated calcium channel subunit alpha-2/delta-2
Swissprots Q9NY47 Q9UEW0 Q9NY48 A7MD15 Q9Y268
Accessions EAW65118 EAW65119 EAW65120 EAW65121 Q9NY47 AB011130 BAA25484 AF040709 AAC70914 AF042792 AAB96913 AF042793 AAB96914 AJ251367 CAB86192 AJ251368 CAB86193 AK074820 AK310138 AW451435 AW952467 BC152438 AAI52439 BF373910 DA760583 XM_005265581 XP_005265638 XM_011534242 XP_011532544 XM_011534243 XP_011532545 XM_011534244 XP_011532546 NM_001005505 NP_001005505 NM_001174051 NP_001167522 NM_001291101 NP_001278030 NM_006030 NP_006021
Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. {ECO:0000269|PubMed:12555074, ECO:0000269|PubMed:15111129}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with CACNA1A in lipid raft fractions. {ECO:0000250}.
Tissue Specificity Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain. {ECO:0000269|PubMed:10766861, ECO:0000269|PubMed:11687876, ECO:0000269|PubMed:9880589}.
Top Pathways MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy

Cacna2d2 (G-5) - sc-365911 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cacna2d2 (G-5): sc-365911. Western blot analysis of Cacna2d2 expression in SHP-77 whole cell lysate.

Cacna2d2 (C-18) - sc-34768 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Cacna2d2 (H-210) - sc-66822 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cacna2d2 (H-210): sc-66822. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic and membrane staining of Purkinje cells and cells in molecular layer.

Cacna2d2 (42) - sc-136423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cacna2d2 (42): sc-136423. Western blot analysis of Cacna2d2 expression in rat cerebrum tissue extract.

Anti-CACNA2D2 antibody - ab129237 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CACNA2D2 antibody (ab129237) at 1/100 dilution + Mouse kidney tissue lysate at 35 µgdeveloped using the ECL technique

Anti-CACNA2D2 antibody [EPR12343] - ab173293 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12343
All lanes : Anti-CACNA2D2 antibody [EPR12343] (ab173293) at 1/1000 dilutionLane 1 : Fetal lung lysateLane 2 : Fetal brain lysateLane 3 : Human cerebellum lysateLysates/proteins at 10 µg per lane.

Anti-CACNA2D2 antibody [EPR12343-17] - ab181201 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR12343-17
All lanes : Anti-CACNA2D2 antibody [EPR12343-17] (ab181201) at 1/10000 dilutionLane 1 : Human cerebellum lysateLane 2 : Human fetal brain lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-CACNA2D2 antibody - C-terminal - ab134254 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CACNA2D2 antibody - C-terminal (ab134254) at 1 µg/ml + HCT15 cell lysate at 10 µg

Anti-CACNA2D2 Antibody (aa643-671, APC) - LS-C253283 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D2 Antibody (aa643-671, AP) - LS-C253284 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D2 Antibody (aa643-671, FITC) - LS-C253286 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D2 Antibody (aa643-671, Biotin) - LS-C253285 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D2 Antibody (aa643-671, PE) - LS-C253287 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D2 Antibody (aa643-671, Azide-free, HRP) - LS-C253288 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D2 Antibody (aa642-671) - LS-C319971 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA2D2 Antibody (aa1030-1079) - LS-C151175 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CACNA2D2 antibody Western Blot of HCT15.

Anti-CACNA2D2 Antibody (clone 3A4) IHC-plus™ - LS-B6028 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3A4
Anti-CACNA2D2 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6028 concentration 5 ug/ml.

Anti-CACNA2D2 Antibody (aa643-671) - LS-C168258 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
CACNA2D2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human cerebellum tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

CACNA2D2 Antibody - NBP2-30044 from Novus Biologicals

Prices $299.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CACNA2D2 Antibody [NBP2-30044] - Western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CACNA2D2 antibody detected the CACNA2D2 protein (arrow).

CACNA2D2 Antibody - NBP1-81501 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CACNA2D2 Antibody - NBP1-20110 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CACNA2D2 Antibody (4E3) - H00009254-M12 from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4E3

CACNA2D2 Antibody (3A4) - H00009254-M05 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3A4

Monoclonal Anti-CACNA2D2 antibody produced in mouse - SAB1401462 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4E3
<B>Immunoblotting</B><BR/>Monoclonal Anti-CACNA2D2, antibody produced in mouse, clone 4E3, purified immunoglobulin: <B>Cat. No. SAB1401462</B>: Antibody concentration: 1.0 - 5.0 μg/mL. Using HeLa lysate.

Monoclonal Anti-CACNA2D2 antibody produced in mouse - SAB1401461 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3A4
<B>Immunoblotting</B><BR/>Monoclonal Anti-CACNA2D2, antibody produced in mouse, clone 3A4, purified immunoglobulin: <B>Cat. No. SAB1401461</B>: Antibody concentration: 1.0 μg/mL. Specific band of ~36.89 kDa using immunogen protein lysate.
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