ACE2

Gene Symbol ACE2
Entrez Gene 59272
Alt Symbol ACEH
Species Human
Gene Type protein-coding
Description angiotensin I converting enzyme 2
Other Description ACE-related carboxypeptidase|angiotensin I converting enzyme (peptidyl-dipeptidase A) 2|angiotensin-converting enzyme 2|angiotensin-converting enzyme homolog|metalloprotease MPROT15|peptidyl-dipeptidase A
Swissprots Q9NRA7 Q9UFZ6 C7ECU1 Q86WT0 Q6UWP0 Q9BYF1
Accessions AAO25651 CAC18991 CAD35458 CAD37288 EAW98891 EAW98892 Q9BYF1 AB046569 BAB40370 AB193259 BAD99266 AB193260 BAD99267 AF241254 AAF78220 AF291820 AAF99721 AK026461 AK315144 BAG37592 AL110224 CAB53682 AY358714 AAQ89076 AY623811 AAT45083 BC032938 BC039902 AAH39902 BC048094 AAH48094 BC048144 BC059378 GQ262784 ACT66268 XM_011545549 XP_011543851 XM_011545550 XP_011543852 XM_011545551 XP_011543853 XM_011545552 XP_011543854 NM_021804 NP_068576
Function Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:24227843}.
Subcellular Location Processed angiotensin-converting enzyme 2: Secreted.
Tissue Specificity Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system. {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:12459472, ECO:0000269|PubMed:15141377, ECO:0000269|PubMed:15231706, ECO:0000269|PubMed:15671045}.
Top Pathways Protein digestion and absorption, Renin-angiotensin system

ACE2 CRISPR/Cas9 KO Plasmid (h) - sc-401131 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE2 HDR Plasmid (h) - sc-401131-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE2 Double Nickase Plasmid (h) - sc-401131-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE2 Double Nickase Plasmid (h2) - sc-401131-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE2 CRISPR Activation Plasmid (h) - sc-401131-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE2 CRISPR Activation Plasmid (h2) - sc-401131-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE2 Lentiviral Activation Particles (h) - sc-401131-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE2 Lentiviral Activation Particles (h2) - sc-401131-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE2 siRNA (h) - sc-41400 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ACE2 shRNA Plasmid (h) - sc-41400-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ACE2 shRNA (h) Lentiviral Particles - sc-41400-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ACE-2 RNAi - H00059272-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU033081 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2478 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1154 from Sigma-Aldrich

Category ZFN Kit
Prices $6,000.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2478 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07254 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07254

ACE2 siRNA (Human) - CRJ1761 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ACE2 - MBS8214145 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ACE2 CRISPR/Cas9 KO Plasmid (h2) - sc-401131-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ACE2 HDR Plasmid (h2) - sc-401131-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human ACE2 (NM_021804.2) - SHH230218 from Creative biogene

Category siRNA
Species Reactivities Human

Human ACE2 siRNA - orb272262 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ACE2 shRNA Plasmid (Human) - CHJ1761 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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