XYLT1

Gene Symbol XYLT1
Entrez Gene 64131
Alt Symbol DBQD2, PXYLT1, XT-I, XT1, XTI, XYLTI
Species Human
Gene Type protein-coding
Description xylosyltransferase I
Other Description O-xylosyltransferase 1|beta-D-xylosyltransferase 1|peptide O-xylosyltransferase 1|xylT-I|xylosyltransferase 1|xylosyltransferase iota
Swissprots Q9H1B6 Q86Y38
Accessions AIZ49756 AJM90214 EAW50949 Q86Y38 AI524006 AJ277441 CAC16787 AJ539163 CAD62248 AK000198 AL050125 BC036692 BC045778 BC156039 AAI56040 BU620961 BX647541 XM_011522574 XP_011520876 NM_022166 NP_071449
Function Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000269|PubMed:16571645}; Single- pass type II membrane protein {ECO:0000250}. Secreted {ECO:0000305|PubMed:10383739}. Note=Some fraction is also found in the extracellular space together with chondroitin sulfate proteoglycans, suggesting that it can be secreted.
Tissue Specificity Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle. {ECO:0000269|PubMed:11099377}.
Top Pathways Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, Glycosaminoglycan biosynthesis - heparan sulfate / heparin

XylT-I (E-5) - sc-390671 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XylT-I (E-5): sc-390671. Western blot analysis of XylT-I expression in JAR (A) and MIA PaCa-2 (B) whole cell lysates.

XylT-I (H-74) - sc-134851 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
XylT-I (H-74): sc-134851. Western blot analysis of XylT-I expression in JAR whole cell lysate.

XylT-I (A-20) - sc-50870 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XylT-I (A-20): sc-50870. Western blot analysis of XylT-I expression in JAR (A) and MIA PaCa-2 (B) whole cell lysates.

XylT-I (C-20) - sc-50871 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XylT-I (C-20): sc-50871. Western blot analysis of XylT-I expression in non-transfected: sc-110760 (A) and mouse XylT-I transfected: sc-179764 (B) 293 whole cell lysates.

XylT-I (E-20) - sc-50872 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XylT-I (E-20): sc-50872. Western blot analysis of XylT-I expression in non-transfected: sc-110760 (A) and mouse XylT-I transfected: sc-179764 (B) 293 whole cell lysates.

Anti-XYLT1 antibody - ab197193 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-XYLT1 antibody (ab197193) at 1/500 dilution + 293 cell lysate

Anti-XYLT1 antibody - ab108263 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-XYLT1 antibody (ab108263) at 1 µg/ml + PANC1 cell lysate at 10 µg

Anti-XYLT1 antibody - N-terminal - ab171196 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-XYLT1 antibody - N-terminal (ab171196) at 1/100 dilution + NCI-H460 cell lysate at 35 µg

Anti-XYLT1 / XylT-I Antibody (aa126-155, AP) - LS-C242809 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XYLT1 / XylT-I Antibody (aa126-155, APC) - LS-C242810 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XYLT1 / XylT-I Antibody (aa126-155, Biotin) - LS-C242811 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XYLT1 / XylT-I Antibody (aa126-155, FITC) - LS-C242812 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XYLT1 / XylT-I Antibody (aa126-155, PE) - LS-C242813 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XYLT1 / XylT-I Antibody (aa126-155, Azide-free, HRP) - LS-C247265 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XYLT1 / XylT-I Antibody (aa133-163) - LS-C326404 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XYLT1 / XylT-I Antibody (aa551-600) - LS-C116914 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
XYLT1 antibody LS-C116914 Western blot of PANC1 cell lysate.

Anti-XYLT1 / XylT-I Antibody (aa126-155) - LS-C160677 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
XYLT1 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The XYLT1 antibody detected the XYLT1 protein (arrow).

xylosyltransferase 1 Antibody - NBP1-91345 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: xylosyltransferase 1 Antibody [NBP1-91345] - PANC1 cell lysate, concentration 0.2-1 ug/ml.

xylosyltransferase 1 Antibody - NBP1-90674 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

xylosyltransferase 1 Antibody - NBP1-90675 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XYLT1 antibody produced in rabbit - HPA007478 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-XYLT1: <B>Cat. No. HPA007478</B>: Immunohistochemical staining of human skeletal muscle shows moderate cytoplasmic positivity.

ANTI-XYLT1(N-TERMINAL) antibody produced in rabbit - SAB1306953 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-XYLT1 (N-term): <B>Cat. No. SAB1306953</B>: XYLT1 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35 μg/lane).

Anti-XYLT1 antibody produced in rabbit - HPA007966 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-XYLT1: <B>Cat. No. HPA007966</B>: Immunohistochemical staining of human skeletal muscle shows moderate positivity.

XYLT1 antibody - middle region (ARP49700_P050) - ARP49700_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

XYLT1-Antibody-N-term - AP12779a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
XYLT1 Antibody (N-term) (Cat. #AP12779a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the XYLT1 antibody detected the XYLT1 protein (arrow).
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