Parp1

Gene Symbol Parp1
Entrez Gene 11545
Alt Symbol 5830444G22Rik, AI893648, ARTD1, Adprp, Adprt1, C80510, PARP, PPOL, parp-1, sPARP-1
Species Mouse
Gene Type protein-coding
Description poly (ADP-ribose) polymerase family, member 1
Other Description ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1|ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1|ADP-ribosyltransferase diphtheria toxin-like 1|ADPRT 1|NAD(+) ADP-ribosyltransferase 1|msPARP|poly [ADP-ribose] polymerase 1|poly[ADP-ribose] synthase 1|poly[ADP-ribose] synthetase 1
Swissprots P11103 Q9JLX4 Q9QVQ3
Accessions EDL13152 P11103 AF126717 AAF61293 AK028042 AK030889 BAC27173 AK088679 BAC40500 AK135977 BAE22758 AK146677 BAE27352 AK152360 BAE31150 AK159433 BAE35080 AK165158 AK166104 BAE38574 AK167699 BAE39743 AK169326 BAE41080 AK195303 AK202655 AK210311 BC012041 AAH12041 X14206 CAA32421 NM_007415 NP_031441
Function Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN- gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (By similarity). Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (By similarity).
Subcellular Location Nucleus. Nucleus, nucleolus {ECO:0000250}. Note=Localizes at sites of DNA damage. {ECO:0000250}.
Tissue Specificity Widely expressed. Expression is correlated with proliferation, with higher levels occurring during early fetal development and organogenesis and in the highly proliferative cell compartments of adult. Expressed in B-cells that have been induced to switch to various Ig isotypes. {ECO:0000269|PubMed:9642267}.
Top Pathways Base excision repair

Cleaved PARP (Asp214) (7C9) Mouse mAb (Mouse Specific) - 9548 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 7C9
Western blot analysis of NIH/3T3 cells, untreated or staurosporine-treated (1 µM), using Cleaved PARP (Asp214) (7C9) Mouse mAb (Mouse Specific).

Cleaved PARP (Asp214) Antibody (Mouse Specific) - 9544 from Cell Signaling Technology

Prices $109.00, $279.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of NIH/3T3 cells, untreated or staurosporine-treated (1 µM, 3hrs), using Cleaved PARP (Asp214) Antibody (Mouse Specific).

Anti-cleaved PARP antibody - ab2322 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Monoclonal Anti-PARP antibody produced in mouse - P248 from Sigma-Aldrich

Prices $506.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone C-2-10

PARP antibody [15B47] - GTX53392 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rat
Clonality Monoclonal
Clone 15B47

PARP antibody - 70R-11641 from Fitzgerald

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

PARP Antibody - abx102686 from Abbexa

Host Rabbit
Clonality Polyclonal

PARP1 antibody - SM5160 from Acris Antibodies

Prices $510.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone C-2-10

PARP1 antibody - SP5460 from Acris Antibodies

Prices $510.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PARP1 antibody - PAB9559 from Acris Antibodies

Prices $580.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

PARP, Monoclonal Antibody - MBS690048 from MyBioSource

Prices $460.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone (15B47)

Poly ADP Ribose Polymerase (PARP), Polyclonal Antibody - MBS2017296 from MyBioSource

Prices $150.00, $290.00, $460.00
Sizes 20 µg, 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

PARP-1 (mouse) polyclonal antibody - ALX-210-619-R100 from Enzo Life Sciences

Prices $280.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PARP-1 antibody - pab10160 from Covalab

Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to Poly ADP Ribose Polymerase (PARP) - PAA279Mu01 from Cloud-clone

Host Rabbit
Clonality Polyclonal

PARP (Cleaved) Antibody - 3141-100 from Biovision

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

PARP (Cleaved), Polyclonal Antibody - MBS840754 from MyBioSource

Prices $420.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

anti-PARP (cleaved) antibody - ARG20042 from Arigo Biolaboratories

Host Rabbit
Clonality Polyclonal

PARP-Cleaved-Antibody - ABV11502 from Abgent, a WuXi AppTec company

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

PARP-1 Antibody - 36-339 from ProSci

Prices $315.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PARP (Cleaved) Antibody - 3141 from Biovision

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Cleaved PARP (Asp214) (D6X6X) Rabbit mAb (Rodent Specific) - 94885 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone D6X6X
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