KMT2B

Gene Symbol KMT2B
Entrez Gene 9757
Alt Symbol CXXC10, HRX2, MLL1B, MLL2, MLL4, TRX2, WBP-7, WBP7
Species Human
Gene Type protein-coding
Description lysine (K)-specific methyltransferase 2B
Other Description WW domain binding protein 7|histone-lysine N-methyltransferase 2B|histone-lysine N-methyltransferase MLL4|mixed lineage leukemia gene homolog 2|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4|myeloid/lymphoid or mixed-lineage leukemia protein 4|trithorax homologue 2
Swissprots Q9Y669 Q96IP3 Q96GP2 O95836 Q9UMN6 Q9UK25 O15022 Q9Y668
Accessions Q9UMN6 AB002302 BAA20763 AF104918 AAD17932 AF105279 AAD26113 AF105280 AAD26112 AF186605 AAD56420 AJ007041 CAB45385 BC007353 AAH07353 BC009337 AAH09337 BC026861 BM967067 XM_011527561 XP_011525863 XM_011527562 XP_011525864 XM_011527563 XP_011525865 XR_935878 NM_014727 NP_055542
Function Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation. {ECO:0000269|PubMed:17707229}.
Subcellular Location Nucleus {ECO:0000250}.
Tissue Specificity Widely expressed. Highest levels in testis. Also found in brain, bone marrow, heart, muscle, kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocytes and pancreas. Often amplified in pancreatic carcinomas.
Top Pathways Lysine degradation

MLL4 CRISPR/Cas9 KO Plasmid (h) - sc-406127 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL4 HDR Plasmid (h) - sc-406127-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL4 Double Nickase Plasmid (h) - sc-406127-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL4 Double Nickase Plasmid (h2) - sc-406127-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL4 CRISPR Activation Plasmid (h) - sc-406127-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL4 CRISPR Activation Plasmid (h2) - sc-406127-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL4 Lentiviral Activation Particles (h) - sc-406127-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL4 Lentiviral Activation Particles (h2) - sc-406127-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL4 siRNA (h) - sc-75796 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MLL4 shRNA Plasmid (h) - sc-75796-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MLL4 shRNA (h) Lentiviral Particles - sc-75796-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN14399 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14399 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02533 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02533

KMT2B siRNA (Human) - CRH6522 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MLL4 (NM_014727.1) - SHH342544 from Creative biogene

Category siRNA
Species Reactivities Human

KMT2B shRNA Plasmid (Human) - CHH6522 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MLL4 miRNA 3'UTR clone - MiUTR1H-06325 from Creative biogene

Species Reactivities Human
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