BAX

Gene Symbol BAX
Entrez Gene 581
Alt Symbol BCL2L4
Species Human
Gene Type protein-coding
Description BCL2-associated X protein
Other Description BCL2-associated X protein omega|Baxdelta2G9|Baxdelta2G9omega|Baxdelta2omega|apoptosis regulator BAX|bcl-2-like protein 4|bcl2-L-4
Swissprots Q9NYG7 Q8WZ49 Q07814 P55269 Q9UCZ7 Q07815 Q9UCZ6 Q07812 Q9UQD6 Q9NR76 A8K4W1
Accessions AAD01415 AAD01416 AAL73333 AAO22992 EAW52415 EAW52416 EAW52417 EAW52418 EAW52419 EAW52420 EAW52421 Q07812 AF007826 AAD22706 AF247393 AAF71267 AF250190 AAF82094 AI565203 AJ417988 CAD10744 AJ586909 CAE52909 AJ586910 CAE52910 AK291076 BAF83765 BC014175 AAH14175 BE396495 BM673184 BM706954 CN281003 HQ889830 ADZ05507 JX524562 AFU81108 KF830846 AIO10778 KF830847 AIO10779 KF830848 AIO10780 L22473 AAA03619 L22474 AAA03620 L22475 AAA03621 T29044 U19599 AAC50142 XM_006723314 XP_006723377 XM_011527191 XP_011525493 NM_001291428 NP_001278357 NM_001291429 NP_001278358 NM_001291430 NP_001278359 NM_001291431 NP_001278360 NM_004324 NP_004315 NM_138761 NP_620116 NM_138763 NP_620118 NM_138764 NP_620119 NR_027882 NM_138762
Function Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:18948948, ECO:0000269|PubMed:21199865, ECO:0000269|PubMed:8358790, ECO:0000269|PubMed:8521816}.
Subcellular Location Isoform Gamma: Cytoplasm.
Tissue Specificity Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:11912183}.
Top Pathways Viral carcinogenesis, Sphingolipid signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Apoptosis, Tuberculosis

SignalSilence ® Bax siRNA I - 6321 from Cell Signaling Technology

Category siRNA
Prices $256.00
Sizes 300 µl (50-100 transfections)
Species Reactivities Human
Fluorescent detection of SignalSilence ® Control siRNA (Fluorescein Conjugate) #6201 in living HeLa cells 24 hours post-transfection, demonstrating nearly 100% transfection efficiency.

SignalSilence® Bax siRNA II - 6514 from Cell Signaling Technology

Category siRNA
Prices $256.00
Sizes 300 µl (3 nmol)
Western blot analysis of extracts from HeLa cells, transfected with 100 nM SignalSilence ® Control siRNA (Fluorescein Conjugate) #6201 (-), SignalSilence ® Bax siRNA I #6321 (+) or SignalSilence ® Bax siRNA II (+), using Bax Antibody #2772 and α-Tubulin (11H10) Rabbit mAb #2125. The Bax Antibody confirms silencing of Bax expression and α-Tubulin (11H10) Rabbit mAb is used to control for loading and specificity of Bax siRNA.

Bax CRISPR/Cas9 KO Plasmid (h) - sc-400042 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bax HDR Plasmid (h) - sc-400042-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bax Double Nickase Plasmid (h) - sc-400042-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bax Double Nickase Plasmid (h2) - sc-400042-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bax CRISPR Activation Plasmid (h) - sc-400042-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bax CRISPR Activation Plasmid (h2) - sc-400042-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bax Lentiviral Activation Particles (h) - sc-400042-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bax Lentiviral Activation Particles (h2) - sc-400042-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bax siRNA (h) - sc-29212 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Bax shRNA Plasmid (h) - sc-29212-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Bax shRNA (h) Lentiviral Particles - sc-29212-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Baxβ siRNA (h) - sc-37289 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Baxβ shRNA Plasmid (h) - sc-37289-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Baxβ shRNA (h) Lentiviral Particles - sc-37289-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Bax siRNA (h2) - sc-44199 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Bax shRNA Plasmid (h2) - sc-44199-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Bax shRNA (h2) Lentiviral Particles - sc-44199-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Bax RNAi - H00000581-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Bax RNAi - H00000581-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Bax RNAi - H00000581-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Bax RNAi - H00000581-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU069421 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1006 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt
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