ARRB1

Gene Symbol ARRB1
Entrez Gene 408
Alt Symbol ARB1, ARR1
Species Human
Gene Type protein-coding
Description arrestin, beta 1
Other Description arrestin 2|beta-arrestin-1
Swissprots Q9BTK8 B6V9G8 O75630 P49407 Q2PP20 O75625
Accessions ABC40724 EAW74960 EAW74961 EAW74962 P49407 AF084040 AAC33295 AF084940 AAC34123 AK074660 AK289718 BAF82407 AK293758 BAH11589 AL157484 BC003636 AAH03636 BM681392 BQ883950 BU594296 BX402200 CB853136 CD365891 CR735690 DA358665 FJ348262 ACI96306 HQ447288 ADQ31775 L04685 AAA35558 XM_005273997 XP_005274054 XM_011545034 XP_011543336 XM_011545035 XP_011543337 XM_011545036 XP_011543338 NM_004041 NP_004032 NM_020251 NP_064647
Function Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors,
Subcellular Location Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit {ECO:0000305}. Cell projection, pseudopodium {ECO:0000250}. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). {ECO:0000250}.
Top Pathways MAPK signaling pathway, Endocytosis, Chemokine signaling pathway, Phototransduction, Morphine addiction

β-Arrestin 1/2 (D24H9) Rabbit mAb - 4674 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D24H9
Western blot analysis of extracts from various cell lines using beta-Arrestin 1/2 (D24H9) Rabbit mAb.

β-Arrestin 1 (D8O3J) Rabbit mAb - 12697 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8O3J
Western blot analysis of extracts from MDA-MB-435, Hep G2, and PANC-1 cells using β-Arrestin 1 (D8O3J) Rabbit mAb.

Phospho-β-Arrestin 1 (Ser412) (6-24) Mouse mAb - 2416 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 6-24
Western blot analysis of extracts from HEK293 cells alone (-), expressing β-arrestin 1 (wt) or β-arrestin (Ser412Ala) mutant (Ala412), using Phospho-β-Arrestin 1 (Ser412) (6-24) Mouse mAb. Lanes 1 and 3 show endogenous levels of phosphorylated β-arrestin 1.

β-Arrestin-1 (K-16) - sc-9182 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
β-Arrestin-1 (K-16): sc-9182. Western blot analysis ofβ-Arrestin-1 expression in RAW 264.7 whole cell lysate.

β-Arrestin-1 (N-19) - sc-6389 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

β-Arrestin-1 (C-19) - sc-6388 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
β-Arrestin-1 (C-19): sc-6388. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic and membrane staining of cells in glomeruli and cells in tubules.

β-Arrestin-1 (25-G10) - sc-53780 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

β-Arrestin-1/2 (A-1) - sc-74591 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
β-Arrestin-1/2 (A-1): sc-74591. Western blot analysis of β-Arrestin-1/2 expression in RAW 264.7 (A) and PC-12 (B) whole cell lysates.

β-Arrestin-1/2 (21-B1) - sc-53781 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
β-Arrestin-1/2 (21-B1): sc-53781. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic staining of Purkinje cells.

β-Arrestin-1/2 (H-290) - sc-28869 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
β-Arrestin-1/2 (H-290): sc-28869. Western blot analysis of β-Arrestin-1/2 expression in rat skeletal muscle tissue extract.

Anti-beta Arrestin 1 (phospho S412) antibody - ab59172 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human breast carcinoma tissue using ab59172 at 1/50-1/100 dilution. Samples treated with phospho-peptide (+) or without phospho-peptide (-).

Anti-beta Arrestin 1 (phospho S412) antibody [E109] - ab32097 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E109
Anti-beta Arrestin 1 (phospho S412) antibody [E109] (ab32097) at 1/20000 dilution + 293T cell lysate.

Anti-beta Arrestin 1 antibody - ab64999 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-beta Arrestin 1 antibody (ab64999) at 1/500 dilutionLane 1 : Extracts from Jurkat cellsLane 2 : Extracts from HUVEC cellsLane 3 : Extracts from HUVEC cells with immunizing peptide at 5 µgLysates/proteins at 10 µg per lane.

Anti-beta Arrestin 1 antibody - ab176704 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-beta Arrestin 1 antibody (ab176704) at 0.1 µg/mlLane 1 : 293T whole cell lysate at 50 µgLane 2 : 293T whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-beta Arrestin 1 antibody - ab59209 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab59209 at 1/50 dilution staining beta Arrestin 1 in Human brain by Immunohistochemistry, Paraffin embedded tissue, in the absence or presence of the immunizing peptide.

Anti-beta Arrestin 1 antibody - ab134700 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-beta Arrestin 1 antibody (ab134700) at 1/500 dilution + HepG2 cell extract at 30 µg

Anti-beta Arrestin 1 antibody - ab167346 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-beta Arrestin 1 antibody (ab167346) at 1 µg/mlLane 1 : beta Arrestin 1 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-beta Arrestin 1 antibody [1H4-F5-C11] - ab131180 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1H4-F5-C11
All lanes : Anti-beta Arrestin 1 antibody [1H4-F5-C11] (ab131180) at 1/1000 dilutionLane 1 : PC12 cell lysateLane 2 : Mouse brain lysateLane 3 : RAW 264.7 cell lysate

Anti-beta Arrestin 1 antibody [1H4-F5-C11] - ab176465 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1H4-F5-C11
All lanes : Anti-beta Arrestin 1 antibody [1H4-F5-C11] (ab176465) at 1/500 dilutionLane 1 : Mouse brain cell lysateLane 2 : Raw 264.7 cell lysateLane 3 : MCF7 cell lysateLane 4 : PC12 cell lysate

Anti-beta Arrestin 1 antibody - C-terminal - ab170805 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of A549 cells labeling beta Arrestin 1 using ab170805 at a 1/10 dilution (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used.

Anti-pan Arrestin antibody - ab2914 from Abcam

Prices $380.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of pan Arrestin showing staining in the cytoplasm and nucleus of paraffin-treated human cerebellum tissue (right) compared with a negative control in the absence of primary antibody (left). Antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then incubated with ab2914 diluted by 3% BSA-PBS at a dilution of 1:500 overnight at 4°C in a humidified chamber. Tissues were washed extensively in PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.

Anti-ARRB1 / Beta Arrestin 1 Antibody (phospho-Ser412) - LS-C20787 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-ARRB1 / Beta Arrestin 1 Antibody (phospho-Ser412) - LS-C20788 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ARRB1 / Beta Arrestin 1 Antibody (C-Terminus) - LS-C35063 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ARRB1 / Beta Arrestin 1 Antibody - LS-C69269 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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