Gene Symbol | TNNC1 |
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Entrez Gene | 7134 |
Alt Symbol | CMD1Z, CMH13, TN-C, TNC, TNNC |
Species | Human |
Gene Type | protein-coding |
Description | troponin C type 1 (slow) |
Other Description | cardiac troponin C|slow twitch skeletal/cardiac muscle troponin C|troponin C, slow skeletal and cardiac muscles|troponin C1, slow |
Swissprots | P63316 |
Accessions | AAA36772 ADL14491 EAW65226 EAW65227 P63316 AF020769 AAB91994 AJ574625 AK313743 BAG36483 BC030244 AAH30244 CR541865 CAG46663 CR541885 CAG46683 DQ891026 ABM81952 DQ894206 ABM85132 X07897 CAA30736 NM_003280 NP_003271 |
Function | Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. |
Top Pathways | Calcium signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, Adrenergic signaling in cardiomyocytes |
Troponin C CRISPR/Cas9 KO Plasmid (h) - sc-406429 from Santa Cruz Biotechnology
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Troponin C HDR Plasmid (h) - sc-406429-HDR from Santa Cruz Biotechnology
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Troponin C Double Nickase Plasmid (h) - sc-406429-NIC from Santa Cruz Biotechnology
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Troponin C Double Nickase Plasmid (h2) - sc-406429-NIC-2 from Santa Cruz Biotechnology
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Troponin C CRISPR Activation Plasmid (h) - sc-406429-ACT from Santa Cruz Biotechnology
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Troponin C CRISPR Activation Plasmid (h2) - sc-406429-ACT-2 from Santa Cruz Biotechnology
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Troponin C Lentiviral Activation Particles (h) - sc-406429-LAC from Santa Cruz Biotechnology
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Troponin C Lentiviral Activation Particles (h2) - sc-406429-LAC-2 from Santa Cruz Biotechnology
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Troponin C slow skeletal/cardiac siRNA (h) - sc-43513 from Santa Cruz Biotechnology
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Troponin C slow skeletal/cardiac shRNA Plasmid (h) - sc-43513-SH from Santa Cruz Biotechnology
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Troponin C slow skeletal/cardiac shRNA (h) Lentiviral Particles - sc-43513-V from Santa Cruz Biotechnology
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Tenascin C RNAi - H00003371-R01 from Novus Biologicals
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MISSION® esiRNA - EHU009031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21782 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21782 from Sigma-Aldrich
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TNNC1 siRNA (Human) - CRH4893 from Cohesion Biosciences
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TNNC1 - MBS8227119 from MyBioSource
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shRNA set against Human TNNC1 (NM_003280.2) - SHH432344 from Creative biogene
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Human TNNC1 siRNA - orb265395 from Biorbyt
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TNNC1 shRNA Plasmid (Human) - CHH4893 from Cohesion Biosciences
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TNNC1 miRNA 3'UTR clone - MiUTR3H-02294 from Creative biogene
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