ROS1

Gene Symbol	ROS1
Entrez Gene	6098
Alt Symbol	MCF3, ROS, c-ros-1
Species	Human
Gene Type	protein-coding
Description	ROS proto-oncogene 1 , receptor tyrosine kinase
Other Description	c-ros oncogene 1 , receptor tyrosine kinase|proto-oncogene c-Ros-1|proto-oncogene tyrosine-protein kinase ROS|transmembrane tyrosine-specific protein kinase|v-ros avian UR2 sarcoma virus oncogene homolog 1
Swissprots	Q15368 P08922 Q5TDB5
Accessions	AAA60277 EAW48208 EAW48209 P08922 BC144556 BC166687 AAI66687 M13880 AAA36580 M34353 AAA60278 XM_006715548 XP_006715611 XM_011536049 XP_011534351 XM_011536050 XP_011534352 XM_011536051 XP_011534353 XM_011536052 XP_011534354 XM_011536053 XP_011534355 XM_011536054 XP_011534356 XM_011536055 XP_011534357 XM_011536056 XP_011534358 XM_011536057 XP_011534359 XM_011536058 XP_011534360 NM_002944 NP_002935
Function	Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}.
Subcellular Location	Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in brain. Expression is increased in primary gliomas. {ECO:0000269|PubMed:8143271}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ROS protein fragment - ab125624 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human ROS protein fragment - ab196092 from Abcam Category Protein Prices $612.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

ROS1 / ROS Antibody Blocking Peptide - LS-E9182 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ROS1 / ROS Antibody Blocking Peptide - LS-E27905 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ROS Peptide - P2717 from Novus Biologicals Category Peptide Species Human

ROS-Antibody-N-term-Blocking-Peptide - BP7676a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ROS1 peptide - orb218869 from Biorbyt Category Peptide Prices $306.00, $519.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Cat

ROS (phospho-Tyr2114) Blocking Peptide - abx064200 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Pig, Rabbit

ROS Peptide - AC21-2891-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ROS1 - P5637 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

ROS1 Active Human Recombinant Protein - GWB-D47510 from Genway Biotech Category Protein Prices $438.00 Sizes 10 µg Species Human

Recombinant Human C-Ros Oncogene 1, Receptor Tyrosine Kinase, GST-tagged - ROS1-1091H from Creative Biomart Category Protein Species Human

Recombinant C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1) - RPE273Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1) - RPE273Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Ros Protein, active, 10 µg - 14-527 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg also available in 250 µg size --call for pricing and availability and reference catalog numbe Source expressed by baculovirus in Sf21 insect cells

Ros Protein, active, 250 µg - 14-527M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-527) and in bulk (cat# 14-527-K) Source expressed by baculovirus in Sf21 insect cells

ROS (pY2114) Blocking Peptide - CBP3006 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Chicken, Pig, Rabbit

Recombinant C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1) - RPE273Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Proto-oncogene tyrosine-protein kinase ROS(ROS1) ,partial - CSB-YP020072HU CSB-EP020072HU CSB-BP020072HU CSB-MP020072HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Active human ROS (mutated G2032 R) protein fragment - ab206012 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

ROS1, Peptide - MBS427937 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

ROS Recombinant Protein Antigen - NBP2-13245PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ROS1-Blocking-Peptide-C-term - BP20883c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ROS1 Peptide, Human - M34GP13474H from Creative Peptides Category Peptide Source Synthetic. Species Human

ROS1 fusion protein - Ag25722 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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