| Gene Symbol |
ARAP1
|
| Entrez Gene |
116985
|
| Alt Symbol |
CENTD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
|
| Other Description |
ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1|arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1|centaurin, delta 2|centaurin-delta-2|cnt-d2
|
| Swissprots |
O94879 Q59FI7 Q96L71 Q8WU51 A3KLL7 Q6PHS3 B2RTS2 Q4LDD5 Q96HP6 Q96P48
|
| Accessions |
EAW74863 EAW74864 EAW74865 EAW74866 Q96P48 AB018325 BAA34502 AF411983 AAL04167 AJ621557 CAF21317 AJ706973 AK160383 BAD18726 AY049732 AAL12169 AY553630 AAT36325 BC008315 AAH08315 BC021244 BC056401 AAH56401 BC140792 AAI40793 BC144562 AAI44563 BQ921498 CD251362 DA186424 NM_001040118 NP_001035207 NM_001135190 NP_001128662 NM_015242 NP_056057
|
| Function |
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.
|
| Tissue Specificity |
Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea. {ECO:0000269|PubMed:11804590}.
|
| Top Pathways |
Endocytosis
|