| Gene Symbol | NOTCH4 |
|---|---|
| Entrez Gene | 4855 |
| Alt Symbol | INT3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | notch 4 |
| Other Description | Notch homolog 4|neurogenic locus notch homolog protein 4 |
| Swissprots | Q9H3S8 B0V183 Q99458 Q5SSY7 B0V1X5 Q99466 Q9UIJ0 O00306 Q9UII9 Q99940 |
| Accessions | AAC63097 BAA13116 BAA88951 BAA88952 BAB20317 Q99466 AK131314 AK290785 BAF83474 AK293692 BAG57129 AK294161 BAG57484 AL705928 BC033869 BC063815 AAH63815 BC140782 AAI40783 BC144540 BC144541 BQ023880 D63395 BAA09708 U95299 AAC32288 NM_004557 NP_004548 |
| Function | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes. |
| Top Pathways | Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation |