| Gene Symbol | HTR7 |
|---|---|
| Entrez Gene | 3363 |
| Alt Symbol | 5-HT7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled |
| Other Description | 5-HT-7|5-HT-X|5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)|5-hydroxytryptamine receptor 7 |
| Swissprots | Q5VX02 P78516 P34969 Q5VX01 P78372 B5BUP6 P78336 Q5VX03 |
| Accessions | AAB48397 AAF07217 AAF07218 CAA66865 EAW50118 EAW50119 EAW50120 P34969 AB451482 BAG70296 AK292606 BAF85295 AY493988 AAR87480 BC047526 AAH47526 BG108256 L21195 AAC37538 U68487 AAB48393 U68488 AAB48394 NM_000872 NP_000863 NM_019859 NP_062873 NM_019860 NP_062874 |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression. {ECO:0000269|PubMed:9084407}. |
| Top Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |