POMC

Gene Symbol POMC
Entrez Gene 5443
Alt Symbol ACTH, CLIP, LPH, MSH, NPP, POC
Species Human
Gene Type protein-coding
Description proopiomelanocortin
Other Description adrenocorticotropic hormone|adrenocorticotropin|alpha-MSH|alpha-melanocyte-stimulating hormone|beta-LPH|beta-MSH|beta-endorphin|beta-melanocyte-stimulating hormone|corticotropin-like intermediary peptide|corticotropin-lipotropin|gamma-LPH|gamma-MSH|lipotropin beta|lipotropin gamma|melanotropin alpha|melanotropin beta|melanotropin gamma|met-enkephalin|opiomelanocortin prepropeptide|pro-ACTH-endorphin|pro-opiomelanocortin|proopiomelanocortin preproprotein
Swissprots P78442 P01189 Q9UD40 Q53T23 Q9UD39
Accessions AAB59621 AAY24354 AFV77533 AFV77534 AFV77535 AFV77536 AFV77537 AFV77538 AFV77539 AFV77540 AFV77541 AFV77542 AFV77543 AFV77544 AFV77545 AFV77546 AFV77547 AFV77548 AFV77549 AFV77550 AFV77551 AFV77552 CAA24754 EAX00729 EAX00730 P01189 AI341269 AW951218 BC065832 AAH65832 BT019918 AAV38721 CB988233 CR541826 CAG46625 DQ884404 ABI63371 M25896 AAA35799 M28636 AAA60139 M38297 AAA60140 S76492 AAC60644 XM_011532917 XP_011531219 NM_000939 NP_000930 NM_001035256 NP_001030333
Function Beta-endorphin and Met-enkephalin are endogenous opiates.
Subcellular Location Secreted.
Tissue Specificity ACTH and MSH are produced by the pituitary gland.
Top Pathways Melanogenesis, Adipocytokine signaling pathway

ACTH (O2A3) - sc-57018 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACTH (02A3): sc-57018. Western blot analysis of ACTH expression in rat pituitary tissue extract.

ACTH (2F6) - sc-69648 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACTH (2F6): sc-69648. Western blot analysis of POMC expression in non-transfected: sc-117752 (A) and human POMC transfected: sc-111490 (B) 293T whole cell lysates.

ACTH (B427) - sc-57021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACTH (B427): sc-57021. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing staining of plasma in blood vessels.

ACTH (P-12) - sc-33034 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ACTH (SPM333) - sc-52980 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACTH (SPM333): sc-52980. Western blot analysis of ACTH expression in AtT-20/D16vF2 whole cell lysate (A) and rat pituitary tissue extract (B).

ACTH/CLIP (E-12) - sc-365831 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACTH/CLIP (E-12): sc-365831. Western blot analysis of ACTH/CLIP expression in rat pituitary tissue extract.

ACTH/CLIP (E-15) - sc-18262 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACTH/CLIP (E-15): sc-18262. Western blot analysis of POMC precursor expression in rat pituitary tissue extract.

ACTH/CLIP (F-3) - sc-373878 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACTH/CLIP (F-3): sc-373878. Western blot analysis of POMC expression in rat pituitary tissue extract.

ACTH/CLIP (G-11) - sc-373879 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACTH/CLIP (G-11): sc-373879. Western blot analysis of POMC expression in rat pituitary tissue extract.

ACTH (HAT C22) - sc-69902 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
ACTH (HAT C22): sc-69902. Western blot analysis of POMC expression in non-transfected: sc-117752 (A) and human POMC transfected: sc-111490 (B) 293T whole cell lysates.

POMC (FL-267) - sc-20148 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
POMC (FL-267): sc-20148. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

POMC (G-16) - sc-18263 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

β-endorphin (B31.15) - sc-51680 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

β-endorphin (2Q2194) - sc-71044 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

β-endorphin/Metenkephalin/β-LPH (C-15) - sc-18264 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
β-endorphin/Metenkephalin/β-LPH (C-15): sc-18264. Immunoperoxidase staining of formalin-fixed, paraffin-embedded rat brain tissue showing positive stainedcells inthe cortex.Image kindly provided by Regina Vontell, Adrienne Betz and John Salamone, University of Connecticut

Lipotropin γ (E-19) - sc-33036 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Lipotropin γ (E-19): sc-33036. Western blot analysis of POMC expression in non-transfected: sc-117750 (A) and human POMC transfected: sc-111490 (B) whole cell lysates.

γMSH (Y-17) - sc-16959 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
γ-MSH (Y-17): sc-16959. Western blot analysis of γ-MSH expression in SW-13 whole cell lysate (A) and rat adrenal gland (B), mouse pituitary (C) and mouse lung (D) tissue extracts.

Anti-ACTH (phospho S168) antibody - ab110880 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Dot Blot analysis of ab110880 at 0.5ug per ml on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed.

Anti-ACTH antibody - ab74976 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab74976 staining ACTH in P0 Pitx2-Cre/Dicer1 mutant mice pituitary tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).Samples were fixed in 4% paraformaldehyde, dehydrated, and embedded in paraffin wax. Sections were cut (7 µm) and stained with H&E. Immunohistochemistry was done on 7-µm paraffin sections stained by an indirect immunoperoxidase method. Peroxidase activity was visualized with AEC stain kit. ab74976 diluted 1/200. Secondary antibodies conjugated with biotin were used at 1/150 dilution.

Anti-ACTH antibody - ab75683 from Abcam

Prices $376.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal
ab75683, at 1/500 dilution, staining ACTH in Human pituitary by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

Anti-ACTH antibody - ab2407 from Abcam

Prices $370.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-ACTH antibody [56] - ab21003 from Abcam

Prices $372.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 56

Anti-ACTH antibody [57] - ab20358 from Abcam

Prices $378.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 57
Ab20358 staining human normal pituitary gland. Staining is localised to the cytoplasm and is secreted.Left panel: with primary antibody at 1 ug/ml. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 antigen retrieval buffer citrate pH 6.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 minutes and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be

Anti-ACTH antibody [6Y8] - N-terminal (HRP) - ab187929 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6Y8

Anti-ACTH antibody [AH26] - ab76554 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone AH26
Anti ACTH, at 0.4 µg/ml, staining ACTH in formalin fixed, paraffin embedded human pituitary gland by Immunohistochemistry. Peroxidase conjugating and AEC chromogen were used. Note cytoplasmic staining of anterior pituitary cells. Note: Anti ACTH used to generate this image differed from ab76554 only due to the presence of BSA and azide.
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