ITGB1BP1

Gene Symbol ITGB1BP1
Entrez Gene 9270
Alt Symbol ICAP-1A, ICAP-1B, ICAP-1alpha, ICAP1, ICAP1A, ICAP1B
Species Human
Gene Type protein-coding
Description integrin beta 1 binding protein 1
Other Description ICAP-1|bodenin|integrin beta-1-binding protein 1|integrin cytoplasmic domain-associated protein 1|integrin cytoplasmic domain-associated protein 1-alpha|integrin cytoplasmic domain-associated protein 1-beta
Swissprots O14714 Q53RS0 O14713 D6W4Y9
Accessions AAY14857 EAX00991 EAX00992 EAX00993 EAX00994 EAX00995 EAX00996 EAX00997 EAX00998 EAX00999 EAX01000 EAX01001 O14713 AF012023 AAB88671 AF012024 AAB88672 AK092115 AK093179 AK289817 BAF82506 AK299017 BAG61097 BC012264 AAH12264 BG032225 BM823938 BQ425555 BX647099 CR457006 CAG33287 DA751320 DQ894485 ABM85411 EU176272 ABW03723 XM_005246183 XP_005246240 XM_005246184 XP_005246241 XM_005246185 XP_005246242 XM_005246186 XP_005246243 XM_005246187 XP_005246244 XM_005246188 XP_005246245 XM_005246189 XP_005246246 XM_006711903 XP_006711966 XM_011510416 XP_011508718 NM_004763 NP_004754 NM_022334 NP_071729
Function Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin- dependent manner. Involved in the regulation of beta-1 integrin- containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPa
Subcellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, lamellipodium. Cell projection, ruffle. Note=Nucleocytoplasmic shuttling protein; shuttles between nucleus and cytoplasm in a integrin-dependent manner; probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin; cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 integrin-rich peripheral ruffles and lamellipodia during initial cell spreading on fibronectin and/or collagen.
Tissue Specificity Expressed in endothelial cells and fibroblasts (at protein level). Ubiquitously expressed. Expressed in intestine, colon, testis, ovary, thymus, spleen and prostate. {ECO:0000269|PubMed:9281591, ECO:0000269|PubMed:9867804}.

ICAP-1 (A-20) - sc-67914 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ICAP-1 (A-20): sc-67914. Western blot analysis of ICAP-1 expression in rat small intestine tissue extract.

ICAP-1 (L-18) - sc-67916 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ICAP-1 (L-18): sc-67916. Western blot analysis of ICAP-1 expression in rat small intestine tissue extract.

ICAP-1 (FL-200) - sc-68411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ICAP-1 (FL-200): sc-68411. Western blot analysis of ICAP-1 expression in mouse brain tissue extract.

ICAP-1 (B-2) - sc-166217 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ICAP-1 (B-2): sc-166217. Western blot analysis of ICAP-1 expression in rat small intestine tissue extract.

Anti-ITGB1BP1 antibody - ab56513 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56513 ITGB1BP1 antibody at 1ug/ml.

Anti-ITGB1BP1 / ICAP1 Antibody (aa1-127) - LS-C182876 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-ITGB1BP1 / ICAP1 Antibody (aa107-136, AP) - LS-C260502 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGB1BP1 / ICAP1 Antibody (aa107-136, APC) - LS-C260503 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGB1BP1 / ICAP1 Antibody (aa107-136, Biotin) - LS-C260504 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGB1BP1 / ICAP1 Antibody (aa107-136, FITC) - LS-C260505 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGB1BP1 / ICAP1 Antibody (aa107-136, Azide-free, HRP) - LS-C260506 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGB1BP1 / ICAP1 Antibody (aa107-136, PE) - LS-C260508 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGB1BP1 / ICAP1 Antibody - LS-C308543 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ITGB1BP1 / ICAP1 Antibody (aa107-136) - LS-C329701 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGB1BP1 / ICAP1 Antibody (clone 7A7) - LS-C338867 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7A7
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ITGB1BP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ITGB1BP1.

Anti-ITGB1BP1 / ICAP1 Antibody (clone 1D10) - LS-C338863 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ITGB1BP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ITGB1BP1.

Anti-ITGB1BP1 / ICAP1 Antibody (clone 4E1) - LS-C338887 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ITGB1BP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ITGB1BP1.

Anti-ITGB1BP1 / ICAP1 Antibody (clone 7G9) - LS-C338868 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7G9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ITGB1BP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ITGB1BP1.

Anti-ITGB1BP1 / ICAP1 Antibody (aa108-136) - LS-C159938 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ITGB1BP1 Antibody western blot of MCF-7 cell line lysates (35 ug/lane). The ITGB1BP1 antibody detected the ITGB1BP1 protein (arrow).

Anti-ITGB1BP1 / ICAP1 Antibody (clone 3B3) - LS-C338890 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3B3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ITGB1BP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ITGB1BP1.

Anti-ITGB1BP1 / ICAP1 Antibody (clone 3C11) - LS-C338891 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C11
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ITGB1BP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ITGB1BP1.

Anti-ITGB1BP1 / ICAP1 Antibody (clone 7E8) - LS-C338901 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7E8
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ITGB1BP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ITGB1BP1.

Anti-ITGB1BP1 / ICAP1 Antibody (clone 6A12) - LS-C338853 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6A12
IHC of paraffin-embedded Human tonsil using anti-ITGB1BP1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-ITGB1BP1 / ICAP1 Antibody (aa92-105) IHC-plus™ - LS-B815 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ITGB1BP1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B815 concentration 10 ug/ml.

ICAP-1 Antibody - AF6805 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of human small intestine tissue, human testis tissue, human spleen tissue, and human prostate tissue. PVDF Membrane was probed with 2 µg/mL of Sheep Anti-Human ICAP‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6805) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for ICAP‑1 at approximately 25 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
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