| Gene Symbol | Acot7 |
|---|---|
| Entrez Gene | 26759 |
| Alt Symbol | Bach |
| Species | Rat |
| Gene Type | protein-coding |
| Description | acyl-CoA thioesterase 7 |
| Other Description | ACH1|ACT|CTE-II|CTE-IIa|CTE-IIb|LACH1|MTE-II|brain acyl-CoA hydrolase|cytosolic acyl coenzyme A thioester hydrolase|long chain acyl-CoA thioester hydrolase |
| Swissprots | O08652 O09041 Q64559 |
| Accessions | EDL81226 EDL81227 Q64559 BC087716 AAH87716 CK469690 D88891 BAA19627 DY317682 FQ212652 FQ231740 U49694 AAC53202 Y09332 CAA70512 XM_006239447 XP_006239509 XM_006239448 XP_006239510 NM_001146061 NP_001139533 NM_013214 NP_037346 |
| Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Isoform 1 is expressed constitutively in brain and testis. Isoform 2 is induced in liver by treatment with the peroxisome proliferator. |
| Top Pathways | Fatty acid elongation, Biosynthesis of unsaturated fatty acids |
CompoZr® Knockout ZFN Kit - CKOZFN50144 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND50144 from Sigma-Aldrich
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ACOT7 siRNA (Rat) - CRR0939 from Cohesion Biosciences
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ACOT7 - MBS8219633 from MyBioSource
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shRNA set against Rat ACOT7 (NM_013214.4) - SHH230474 from Creative biogene
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Rat ACOT7 siRNA - orb295788 from Biorbyt
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ACOT7 shRNA Plasmid (Rat) - CHR0939 from Cohesion Biosciences
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