AICDA

Gene Symbol AICDA
Entrez Gene 57379
Alt Symbol AID, ARP2, CDA2, HEL-S-284, HIGM2
Species Human
Gene Type protein-coding
Description activation-induced cytidine deaminase
Other Description cytidine aminohydrolase|epididymis secretory protein Li 284|integrated into Burkitt's lymphoma cell line Ramos|single-stranded DNA cytosine deaminase
Swissprots Q8NFC1 Q9GZX7 Q6QJ81
Accessions BAB12720 BAC66114 CAI75242 CBX87165 EAW88615 Q9GZX7 AB040431 BAB12721 AF529815 AAM95402 AF529816 AAM95403 AF529817 AAM95404 AF529818 AAM95405 AF529819 AAM95406 AF529820 AAM95407 AF529821 AAM95408 AF529822 AAM95409 AF529823 AAM95410 AF529824 AAM95411 AF529825 AAM95412 AF529826 AAM95413 AF529827 AAM95414 AJ577811 CAE12261 AM393608 CAL38484 AY534975 AAS90604 AY536516 AAS92920 AY536517 AAS92921 AY541058 AAS98257 AY748364 AAU95780 BC006296 AAH06296 BT007402 AAP36066 BX402063 DQ431660 ABD92700 DQ892989 ABM83915 DQ896237 ABM87236 EU794587 ACJ13641 XM_011520772 XP_011519074 XM_011520773 XP_011519075 NM_020661 NP_065712
Function Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269|PubMed:18722174, ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21518874}.
Subcellular Location Nucleus. Cytoplasm. Note=Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm.
Tissue Specificity Strongly expressed in lymph nodes and tonsils. {ECO:0000269|PubMed:23166356}.
Top Pathways Primary immunodeficiency, Intestinal immune network for IgA production

AID (L7E7) Mouse mAb - 4975 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone L7E7
Western blot analysis of extracts from P3HR-1 and Ramos cells using AID (L7E7) Mouse mAb.

AID (EK2 5G9) Rat mAb - 4959 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rat
Clonality Monoclonal
Western blot analysis of total cell lysates from P3HR-1 and Ramos cells using AID (EK2 5G9) Rat mAb.

AID (30F12) Rabbit mAb - 4949 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 30F12
Western blot analysis of extracts from various cell types using AID (30F12) Rabbit mAb.

AID (C-20) - sc-14680 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AID (C-20): sc-14680. Western blot analysis of AID expression in Daudi whole cell lysate.

AID (H-80) - sc-25620 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
AID (H-80): sc-25620. Immunofluorescence staining of methanol-fixed Ramos cells showing nuclear and cytoplasmic localization.

AID (A-15) - sc-22912 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

AID (S-18) - sc-31317 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

AID (2D3) - sc-101417 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
AID (2D3): sc-101417. Western blot analysis of AID expression in Hep G2 (A) and Ramos (B) whole cell lysates.

Anti-AICDA antibody - ab93596 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of formalin-fixed paraffin-embedded lymph node showing cytoplasmic staining with ab93596 at 1/100 dilution.

Anti-AICDA antibody - ab183618 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AICDA antibody (ab183618) at 1/1000 dilutionLane 1 : K562 whole cell lysateLane 2 : THP1 whole cell lysateLane 3 : HL60 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-AICDA antibody - ab106273 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AICDA antibody [mAID-2] - ab169522 from Abcam

Prices $376.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone mAID-2
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling N-methyl-D-aspartate receptor NR1 subunit with ab169522 at 20μg/ml, followed by Anti-Rat Biotin and DAB visualization. Nuclei are counterstained with hematoxylin.

Anti-AICDA antibody - Aminoterminal end - ab137397 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-AICDA antibody - Aminoterminal end (ab137397) at 1/500 dilution + 293T whole cell lysate at 30 µg

Anti-AICDA antibody - C-terminal - ab200452 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-AICDA antibody - C-terminal (ab200452) at 1/1000 dilutionLane 1 : mouse brain total cell extractLane 2 : mouse thymus total cell extract

Anti-AICDA antibody - ChIP Grade - ab59361 from Abcam

Prices $390.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AICDA antibody - ChIP Grade (ab59361) at 2 µg/mlLane 1 : Ramos cell lysate Lane 2 : Ramos cell lysate with immunizing peptideLysates/proteins at 15 µg per lane.

Anti-AICDA antibody - ChIP Grade - ab5197 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-AICDA antibody - ChIP Grade (ab5197) at 1 µg/ml + AICDA 293T Cell Transient Overexpression Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

Anti-AICDA / AID Antibody (C-Terminus) IHC-plus™ - LS-B16 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-AICDA antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B16 concentration 5 ug/ml.

Anti-AICDA / AID Antibody (C-Terminus) - LS-C46813 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AICDA / AID Antibody (Asp191) - LS-C34861 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rat
Clonality Monoclonal

Anti-AICDA / AID Antibody (C-Terminus) - LS-C124873 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AICDA / AID Antibody (C-Terminus) - LS-C126589 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AICDA / AID Antibody (aa1-54) - LS-C126588 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-AICDA / AID Antibody (aa8-19) - LS-C54462 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.1 ug/ml) staining of Human Tonsil lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-AICDA / AID Antibody - LS-C126591 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-AICDA / AID Antibody - LS-C126590 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
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