KCNJ2
| Gene Symbol | KCNJ2 |
|---|---|
| Entrez Gene | 3759 |
| Alt Symbol | ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, inwardly rectifying subfamily J, member 2 |
| Other Description | IRK-1|cardiac inward rectifier potassium channel|hIRK1|inward rectifier K+ channel KIR2.1|inward rectifier potassium channel 2|potassium inwardly-rectifying channel, subfamily J, member 2 |
| Swissprots | P63252 P48049 O15110 |
| Accessions | AAF73242 CAJ33689 EAW89092 P63252 AF011904 AAC39555 AF021139 AAB88797 AF153820 AAF73241 AK314081 BAG36779 BC152811 AAI52812 U12507 AAC50072 U16861 AAA91781 U22413 AAA64282 U24055 AAB50277 XM_011524779 XP_011523081 NM_000891 NP_000882 |
| Function | Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. |
| Subcellular Location | Membrane; Multi-pass membrane protein. Membrane; Lipid-anchor {ECO:0000269|PubMed:25043870}. |
| Tissue Specificity | Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain. |
| Top Pathways | Gastric acid secretion, Oxytocin signaling pathway |
KIR2.1 CRISPR/Cas9 KO Plasmid (h) - sc-401974 from Santa Cruz Biotechnology
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KIR2.1 HDR Plasmid (h) - sc-401974-HDR from Santa Cruz Biotechnology
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KIR2.1 Double Nickase Plasmid (h) - sc-401974-NIC from Santa Cruz Biotechnology
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KIR2.1 Double Nickase Plasmid (h2) - sc-401974-NIC-2 from Santa Cruz Biotechnology
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KIR2.1 CRISPR Activation Plasmid (h) - sc-401974-ACT from Santa Cruz Biotechnology
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KIR2.1 CRISPR Activation Plasmid (h2) - sc-401974-ACT-2 from Santa Cruz Biotechnology
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KIR2.1 Lentiviral Activation Particles (h) - sc-401974-LAC from Santa Cruz Biotechnology
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KIR2.1 Lentiviral Activation Particles (h2) - sc-401974-LAC-2 from Santa Cruz Biotechnology
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KIR2.1 siRNA (h) - sc-42612 from Santa Cruz Biotechnology
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KIR2.1 shRNA Plasmid (h) - sc-42612-SH from Santa Cruz Biotechnology
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KIR2.1 shRNA (h) Lentiviral Particles - sc-42612-V from Santa Cruz Biotechnology
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Kir2.1 RNAi - H00003759-R01 from Novus Biologicals
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MISSION® esiRNA - EHU019661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1837 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1837 from Sigma-Aldrich
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KCNJ2 siRNA (Human) - CRH2535 from Cohesion Biosciences
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KIR2.1 CRISPR/Cas9 KO Plasmid (h2) - sc-401974-KO-2 from Santa Cruz Biotechnology
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KIR2.1 HDR Plasmid (h2) - sc-401974-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human KCNJ2 (NM_000891.2) - SHH323275 from Creative biogene
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shRNA set against Human KCNJ2(NM_000891.2) - SHL189804 from Creative biogene
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Human KCNJ2 siRNA - orb263037 from Biorbyt
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KCNJ2 shRNA Plasmid (Human) - CHH2535 from Cohesion Biosciences
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KCNJ2 miRNA 3'UTR clone - MiUTR1H-05137 from Creative biogene
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