| Gene Symbol |
ETF1
|
| Entrez Gene |
2107
|
| Alt Symbol |
D5S1995, ERF, ERF1, RF1, SUP45L1, TB3-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation termination factor 1
|
| Other Description |
eukaryotic peptide chain release factor subunit 1|polypeptide chain release factor 1|protein Cl1|sup45 (yeast omnipotent suppressor 45) homolog-like 1
|
| Swissprots |
Q5M7Z7 P62495 Q96CG1 D3DQC1 B2R6B4
|
| Accessions |
AAD43966 EAW62130 EAW62131 EAW62132 EAW62133 EAW62134 P62495 AK302364 BAH13684 AK309875 AK312510 BAG35411 AL553004 AW131045 BC014269 AAH14269 BC088358 AAH88358 BI460904 BM819293 BT007374 AAP36038 DB060174 DC297662 DQ890706 ABM81632 DQ893890 ABM84816 M75715 AAA36665 U90176 AAB49726 X80916 X81625 CAA57281 XM_005271921 XP_005271978 NM_001256302 NP_001243231 NM_001282185 NP_001269114 NM_001291974 NP_001278903 NM_001291975 NP_001278904 NM_004730 NP_004721
|
| Function |
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. {ECO:0000269|PubMed:7990965}.
|
| Subcellular Location |
Cytoplasm.
|
| Top Pathways |
mRNA surveillance pathway
|
![Western Blot: eRF1 Overexpression Lysate (Adult Normal) [NBL1-10348] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for eRF1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4807_eRF1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10348-img0002.jpg)