| Gene Symbol |
PIK3C2A
|
| Entrez Gene |
5286
|
| Alt Symbol |
CPK, PI3-K-C2(ALPHA), PI3-K-C2A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
|
| Other Description |
C2-containing phosphatidylinositol kinase|PI3K-C2-alpha|PI3K-C2alpha|phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha|phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha|phosphoinositide 3-kinase-C2-alpha|phosphoinositide-3-kinase, class 2, alpha polypeptide|ptdIns-3-kinase C2 subunit alpha
|
| Swissprots |
O00443 B4E2G4 Q14CQ9 B0LPH2
|
| Accessions |
ABY87551 AGC09601 CAB69383 EAW68447 O00443 AK294416 BAG57666 AK299474 BAG61438 AK304262 BAG65126 AK309610 AK310248 AL049998 AL832699 BC031681 BC035982 BC040952 BC113658 AAI13659 BX648778 HQ258691 ADR83442 Y13367 CAA73797 XM_005252977 XP_005253034 XM_005252978 XP_005253035 XM_005252980 XP_005253037 XM_011520186 XP_011518488 XM_011520187 XP_011518489 NM_002645 NP_002636
|
| Function |
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin- mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin- independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on lar
|
| Subcellular Location |
Cell membrane. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Cytoplasm. Note=According to PubMed:10766823 and PubMed:11239472, it is found in the cell membrane, the Golgi apparatus and in clathrin-coated vesicles. According to PubMed:17038310 it inserts preferentially into membranes containing PtdIns(4,5)P2. According to PubMed:11606566, it is nuclear and cytoplasmic. Associated with RNA-containing structures. According to PubMed:14563213, it is mainly cytoplasmic.
|
| Tissue Specificity |
Expressed in columnar and transitional epithelia, mononuclear cells, smooth muscle cells, and endothelial cells lining capillaries and small venules (at protein level). Ubiquitously expressed, with highest levels in heart, placenta and ovary, and lowest levels in the kidney. Detected at low levels in islets of Langerhans from type 2 diabetes mellitus individuals. {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:21127054, ECO:0000269|PubMed:9337861}.
|
| Top Pathways |
Inositol phosphate metabolism, Phosphatidylinositol signaling system
|