Gene Symbol |
Lgals9
|
Entrez Gene |
25476
|
Alt Symbol |
-
|
Species |
Rat
|
Gene Type |
protein-coding
|
Description |
lectin, galactoside-binding, soluble, 9
|
Other Description |
36 kDa beta-galactoside-binding lectin|Lectin galactose binding soluble 9 (Galectin-9)|Lectin, galactose binding, soluble 9 (Galectin-9)|UAT|gal-9|galectin-9|urate transporter/channel
|
Swissprots |
O08588 O35866 P97840
|
Accessions |
EDM05384 P97840 BC061566 AAH61566 U59462 AAB51192 U67958 AAB48591 U72741 AAB68592 NM_012977 NP_037109
|
Function |
Binds galactosides. May play a role in thymocyte- epithelial interactions relevant to the biology of the thymus. Is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death (By similarity). May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Highly selective to the anion urate. {ECO:0000250}.
|
Subcellular Location |
Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=May also be secreted by a non-classical secretory pathway. {ECO:0000250}.
|
Tissue Specificity |
The isoform Long is expressed exclusively in the small intestine.
|