FSCN1

Gene Symbol FSCN1
Entrez Gene 6624
Alt Symbol FAN1, HSN, SNL, p55
Species Human
Gene Type protein-coding
Description fascin actin-bundling protein 1
Other Description 55 kDa actin-bundling protein|fascin|fascin homolog 1, actin-bundling protein|singed-like (fascin homolog, sea urchin)
Swissprots Q9BRF1 B2RE97 Q96IH1 A6NI89 Q96IC5 Q16658
Accessions AAL01526 CBX47601 EAW87344 EAW87345 EAW87346 Q16658 AK095254 BAG53015 AK095830 BAG53141 AK125295 AK316607 BAG38194 BC000521 AAH00521 BC006304 AAH06304 BC007539 AAH07539 BC007643 AAH07643 BC007948 AAH07948 BC007988 AAH07988 BI546742 BT006636 AAP35282 BU629782 DQ891402 ABM82328 DQ894580 ABM85506 U03057 AAA86442 U09873 AAA62201 NM_003088 NP_003079
Function Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}.
Subcellular Location Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol.
Tissue Specificity Ubiquitous.
Top Pathways MicroRNAs in cancer

Fascin (D1A8) Rabbit mAb - 9269 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1A8
Western blot analysis of extracts from various cell lines using Fascin (D1A8) Rabbit mAb.

Fascin 1 (D-10) - sc-46675 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fascin 1 (D-10): sc-46675. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Fascin 1 (C-19) - sc-16579 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Fascin 1 (H-110) - sc-28265 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Fascin 1 (H-110): sc-28265. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Fascin 1 (S-18) - sc-16578 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Fascin 1 (S-18): sc-16578. Immunofluorescence staining of methanol-fixed U-87 MG cells showing cytoplasmic localization.

Fascin 1 (SPM133) - sc-56531 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fascin 1 (SPM133): sc-56531. Western blot analysis of Fascin 1 expression in MES-SA/Dx5 whole cell lysate.

Anti-Fascin (phospho S39) antibody - ab90618 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Fascin antibody - ab183891 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Fascin antibody (ab183891) at 1/1000 dilution + HeLa whole cell lysate/extract at 30 µg

Anti-Fascin antibody - ab97753 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Fascin antibody (ab97753) at 1/1000 dilutionLane 1 : HeLa whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Fascin antibody - ab180226 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Fascin antibody (ab180226) at 1 µg/ml + Human skeletal muscle in RIPA buffer at 35 µg

Anti-Fascin antibody [EP5902] - ab126772 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP5902
Overlay histogram showing HeLa cells stained with ab126772 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab126772, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Fascin antibody [EPR2681] - ab108607 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2681
All lanes : Anti-Fascin antibody [EPR2681] (ab108607) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : SH-SY5Y cell lysateLane 3 : K562 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Fascin antibody [IM20] - ab49815 from Abcam

Prices $390.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone IM20
ICC/IF image of ab49815 stained SKNSH cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab49815 at 1/100 dilution overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- mouse (ab96879) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Fascin antibody - C-terminal - ab166741 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Fascin antibody - C-terminal (ab166741) at 1/1000 dilutionLane 1 : Mouse brain total cell extractLane 2 : Mouse thymus total cell extractLane 3 : HeLa total cell extractLane 4 : Jurkat total cell extract

Anti-FSCN / Fascin Antibody (C-Terminus, clone IM20) - LS-C85108 from LifeSpan Bioscience

Prices $875.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone IM20

Anti-FSCN / Fascin Antibody (clone 55-k2) - LS-C312036 from LifeSpan Bioscience

Prices $245.00, $375.00, $605.00
Sizes 100 µl, 500 µl, 1 ml
Host Mouse
Clonality Monoclonal
Clone 55-k2
IHC of Fascin on FFPE Hodgkin’s Lymphoma tissue.

Anti-FSCN / Fascin Antibody (clone 55-k2, Ready-to-Use) - LS-C348653 from LifeSpan Bioscience

Prices $255.00, $325.00, $465.00
Sizes 3 ml, 7 ml, 15 ml
Host Mouse
Clonality Monoclonal
Clone 55-k2
IHC of Fascin on FFPE Hodgkin's Lymphoma tissue.

Anti-FSCN1 / Fascin Antibody - LS-C36328 from LifeSpan Bioscience

Prices $495.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal

Anti-FSCN1 / Fascin Antibody (phospho-Ser39) - LS-C145095 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FSCN1 / Fascin Antibody (clone 55-k2) - LS-C202858 from LifeSpan Bioscience

Prices $560.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone 55-k2

Anti-FSCN1 / Fascin Antibody (aa93-142) - LS-C134901 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FSCN1 / Fascin antibody LS-C134901 Western blot of Mouse Thymus lysate. Antibody concentration 1 ug/ml.

Anti-FSCN1 / Fascin Antibody (aa27-273, Biotin) - LS-C297158 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FSCN1 / Fascin Antibody (clone SPM133) IHC-plus™ - LS-B5239 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone SPM133
Anti-Fascin antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5239 concentration 10 ug/ml.

Anti-FSCN1 / Fascin Antibody (aa277-396, Biotin) - LS-C300414 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FSCN1 / Fascin Antibody (aa8-260, Biotin) - LS-C297159 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Search more