| Gene Symbol | JTB |
|---|---|
| Entrez Gene | 10899 |
| Alt Symbol | HJTB, HSPC222, PAR, hJT |
| Species | Human |
| Gene Type | protein-coding |
| Description | jumping translocation breakpoint |
| Other Description | jumping translocation breakpoint protein|prostate androgen-regulated protein|protein JTB |
| Swissprots | Q6IB19 O95442 O76095 Q9P0Q4 |
| Accessions | BAA33735 BAA33736 EAW53242 O76095 AB016488 BAA33731 AF115850 AAD09822 AF131797 AAD20045 AF151056 AAF36142 AK312106 BAG35042 BC000499 AAH00499 BC000996 AAH00996 BC001363 AAH01363 BC001667 AAH01667 BC004239 AAH04239 BC019277 AAH19277 BM907938 BT007285 AAP35949 BU527541 CR456985 CAG33266 NM_006694 NP_006685 |
| Function | Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase. |
| Tissue Specificity | Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. {ECO:0000269|PubMed:10321732, ECO:0000269|PubMed:10762645, ECO:0000269|PubMed:17369841, ECO:0000269|PubMed:21225229}. |