| Gene Symbol |
Pir
|
| Entrez Gene |
69656
|
| Alt Symbol |
2310042L19Rik, Pirnl
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
pirin
|
| Other Description |
iron-binding nuclear protein|pirin like|probable quercetin 2,3-dioxygenase PIR|probable quercetinase
|
| Swissprots |
Q9D711 A2AIH9 Q3UAN0 Q8CIE9
|
| Accessions |
AAK54068 EDL40759 Q9D711 AK009757 BAB26481 AK082922 BAC38690 AK090023 BAC41052 AK134541 AK138314 BAE23621 AK151301 BAE30284 BC024062 AAH24062 BY504889 BY718294 BY720928 XM_006528977 XP_006529040 XM_006528978 XP_006529041 NM_001301402 NP_001288331 NM_027153 NP_081429
|
| Function |
Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly localized in dot-like subnuclear structures. {ECO:0000250}.
|
| Tissue Specificity |
Weakly expressed in bone marrow. {ECO:0000269|PubMed:20010624}.
|