TIMP1

Gene Symbol	TIMP1
Entrez Gene	7076
Alt Symbol	CLGI, EPA, EPO, HCI, TIMP
Species	Human
Gene Type	protein-coding
Description	TIMP metallopeptidase inhibitor 1
Other Description	TIMP-1|collagenase inhibitor|erythroid potentiating activity|erythroid-potentiating activity|fibroblast collagenase inhibitor|metalloproteinase inhibitor 1|tissue inhibitor of metalloproteinases 1
Swissprots	P01033 Q9UCU1 Q14252
Accessions	AAA75558 AAX47478 BAA01913 CAR95107 CAS92765 CBX47572 EAW59315 EAW59316 P01033 A10416 CAA00898 AK074854 BAG52016 AK296116 BAG58865 AK307222 AK310206 AK311937 BAG34878 BC000866 AAH00866 BC007097 BQ181804 BU857950 CR407638 CAG28566 CR541982 CAG46779 DQ891122 ABM82048 DQ894301 ABM85227 M12670 AAA52436 M59906 AAA63234 S68252 AAD14009 X02598 CAA26443 X03124 CAA26902 XM_005272645 XP_005272702 NM_003254 NP_003245
Function	Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. {ECO:0000269|PubMed:1420137, ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:17050530, ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:20545310, ECO:0000269|PubMed:22427646, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540, ECO:0000269|PubMed:8576151, ECO:0000269|P
Subcellular Location	Secreted {ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3010309, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540}.
Tissue Specificity	Detected in rheumatoid synovial fluid (at protein level). {ECO:0000269|PubMed:1730286}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TIMP1 Gene - orb91388 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-TIMP1-cDNA-Clone - DC00403 from Abgent, a WuXi AppTec company Prices $280.80 Sizes 10 µg Species Human

TIMP1 - MBS1274739 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC000866

TIMP1 - MBS1275793 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC007097

Human TIMP1 cDNA clone(NM_003254.2) - CDFH019638 from Creative Biomart Species Human Accession NM_003254.2

Human TIMP1 ORF clone(NM_003254.2) - CDCL186456 from Creative Biomart Species Human Accession NM_003254.2

Human TIMP1 ORF Clone(NM_003254.2) - CDCR285227 from Creative Biomart Species Human Accession NM_003254.2

Human TIMP1 ORF Clone(NM_003254.2) - CDCR285228 from Creative Biomart Species Human Accession NM_003254.2

Human TIMP1 ORF Clone(NM_003254.2) - CDCR285229 from Creative Biomart Species Human Accession NM_003254.2

Human TIMP1 ORF Clone(NM_003254.2) - CDCL178520 from Creative Biomart Species Human Accession NM_003254.2

Human TIMP1 ORF Clone(NM_003254.2) - CDCL178521 from Creative Biomart Species Human Accession NM_003254.2

Human TIMP-1/TIMP1 Gene ORF cDNA clone in cloning vector - HG10934-M from Sino Biological Species Human

Human TIMP-1/TIMP1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10934-CH from Sino Biological Species Human

Human TIMP-1/TIMP1 Gene ORF cDNA clone expression plasmid - HG10934-UT from Sino Biological Species Human

Human TIMP-1/TIMP1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10934-M-F from Sino Biological Species Human

Human TIMP1 Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG10934-M-N from Sino Biological Species Human Accession NM_003254.2

Human TIMP-1/TIMP1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10934-ACG from Sino Biological Species Human

Human TIMP-1/TIMP1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10934-NF from Sino Biological Species Human

Human TIMP-1/TIMP1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10934-NM from Sino Biological Species Human

Human TIMP-1/TIMP1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10934-CF from Sino Biological Species Human

Human TIMP-1/TIMP1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10934-CY from Sino Biological Species Human

Human TIMP-1/TIMP1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10934-CM from Sino Biological Species Human

Human TIMP-1/TIMP1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10934-NH from Sino Biological Species Human

Human TIMP-1/TIMP1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10934-NY from Sino Biological Species Human

Human TIMP1 ORF clone(NM_003254.2) - CDCL186456 from Creative biogene Species Human

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