IRG1

Gene Symbol IRG1
Entrez Gene 730249
Alt Symbol CAD
Species Human
Gene Type protein-coding
Description immunoresponsive 1 homolog (mouse)
Other Description aconitate decarboxylase|cis-aconitate decarboxylase|cis-aconitic acid decarboxylase|immune-responsive gene 1 protein homolog
Swissprots A6NK06
Accessions A6NK06 EAW80560 AI652725 BX105915 DN831390 NM_001258406 NP_001245335 XM_011535210 XP_011533512 XM_011535211 XP_011533513
Function Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; IRG1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation. {ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393}.
Subcellular Location Mitochondrion {ECO:0000250}.
Tissue Specificity Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells. {ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393}.

IRG1 CRISPR/Cas9 KO Plasmid (h) - sc-418001 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRG1 HDR Plasmid (h) - sc-418001-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRG1 Double Nickase Plasmid (h) - sc-418001-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRG1 Double Nickase Plasmid (h2) - sc-418001-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRG1 CRISPR Activation Plasmid (h) - sc-418001-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRG1 CRISPR Activation Plasmid (h2) - sc-418001-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRG1 Lentiviral Activation Particles (h) - sc-418001-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRG1 Lentiviral Activation Particles (h2) - sc-418001-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRG1 siRNA (h) - sc-106177 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IRG1 shRNA Plasmid (h) - sc-106177-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IRG1 shRNA (h) Lentiviral Particles - sc-106177-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IRG1 siRNA (Human) - CRJ8756 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IRG1 - MBS8240705 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human IRG1 siRNA - orb279257 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IRG1 shRNA Plasmid (Human) - CHJ8756 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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