SRC

Gene Symbol	SRC
Entrez Gene	6714
Alt Symbol	ASV, SRC1, c-SRC, p60-Src
Species	Human
Gene Type	protein-coding
Description	SRC proto-oncogene, non-receptor tyrosine kinase
Other Description	proto-oncogene c-Src|proto-oncogene tyrosine-protein kinase Src|protooncogene SRC, Rous sarcoma|tyrosine kinase pp60c-src|tyrosine-protein kinase SRC-1|v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Swissprots	Q76P87 E1P5V4 P12931 Q9H5A8 Q86VB9
Accessions	AAA60584 AAB59543 AAC29427 CAA26485 CAN37623 EAW76062 EAW76063 EAW76064 EAW76065 EAW76066 EAW76067 P12931 AF272982 AK024281 BAB14871 AK091756 AW135290 BC011566 AAH11566 BC051270 AAH51270 CD364525 EU831426 ACE87113 EU831519 ACE86438 HY016645 JF432365 ADZ15582 Z18364 XM_011529013 XP_011527315 XM_011529014 XP_011527316 NM_005417 NP_005408 NM_198291 NP_938033
Function	Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasm
Subcellular Location	Cell membrane. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Note=Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites requires myristoylation and the SH3 domain.
Tissue Specificity	Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues.
Top Pathways	Inflammatory mediator regulation of TRP channels, Proteoglycans in cancer, Rap1 signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

c-Src CRISPR/Cas9 KO Plasmid (h) - sc-400165 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Src HDR Plasmid (h) - sc-400165-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Src Double Nickase Plasmid (h) - sc-400165-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Src Double Nickase Plasmid (h2) - sc-400165-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Src CRISPR Activation Plasmid (h) - sc-400165-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Src CRISPR Activation Plasmid (h2) - sc-400165-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Src Lentiviral Activation Particles (h) - sc-400165-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Src Lentiviral Activation Particles (h2) - sc-400165-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Src siRNA (h) - sc-29228 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Src shRNA Plasmid (h) - sc-29228-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Src shRNA (h) Lentiviral Particles - sc-29228-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Src siRNA (h2) - sc-44250 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Src shRNA Plasmid (h2) - sc-44250-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Src shRNA (h2) Lentiviral Particles - sc-44250-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Src RNAi - H00006714-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Src RNAi - H00006714-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® siRNA - SIHK2116 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2115 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2114 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2288 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2288 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10918 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr10918

SRC siRNA (Human) - CRH4583 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SRC - MBS8235487 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human SRC (NM_005417.3) - SHH417648 from Creative biogene Category siRNA Species Reactivities Human

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