| Gene Symbol |
Lin28a
|
| Entrez Gene |
83557
|
| Alt Symbol |
AL024421, ENSMUSG00000070700, Gm10299, Lin-28, Lin28, Tex17, lin-28A
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
lin-28 homolog A (C. elegans)
|
| Other Description |
RNA-binding protein LIN-28|protein lin-28 homolog A|testis expressed gene 17|testis-expressed protein 17
|
| Swissprots |
Q8K3Y3 Q6NV62
|
| Accessions |
EDL30039 Q8K3Y3 AB221669 AF521097 AAM77749 BC068304 AAH68304 XM_006539317 XP_006539380 XM_011250361 XP_011248663 NM_145833 NP_665832
|
| Function |
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, Lin28a down-regulation in neural stem cells by
|
| Subcellular Location |
Cytoplasm. Nucleus, nucleolus. Note=Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules (By similarity). Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes. {ECO:0000250}.
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| Tissue Specificity |
Expressed in embryonic stem cells (ES cells), spermatagonia and testis. Expressed in numerous epithelial tissues including the epithelia of the small intestine, the intralobular duct epithelium of the mammary gland and the epithelia of Henle's loop in the kidney and in the collecting duct (at protein level). Also expressed in the myocardium and skeletal muscle (at protein level). {ECO:0000269|PubMed:11279525, ECO:0000269|PubMed:12798299, ECO:0000269|PubMed:14643679, ECO:0000269|PubMed:15722555}.
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