AIRE

Gene Symbol	AIRE
Entrez Gene	326
Alt Symbol	AIRE1, APECED, APS1, APSI, PGA1
Species	Human
Gene Type	protein-coding
Description	autoimmune regulator
Other Description	autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
Swissprots	O43922 O75745 B2RP50 O43932 O43918
Accessions	BAA23990 BAA23991 BAA23992 BAA95560 BAF62470 CAA08759 EAX09441 EAX09443 O43918 AB006682 BAA23988 AB006683 BAA23989 AB006685 BAA23993 AK309572 BC137268 AAI37269 BC137270 AAI37271 BC142608 Z97990 CAB10790 XM_011529551 XP_011527853 NM_000383 NP_000374 NM_000658 NM_000659
Function	Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions. {ECO:0000250, ECO:0000269|PubMed:11274163, ECO:0000269|PubMed:18292755}.
Subcellular Location	Nucleus. Cytoplasm. Note=Associated with tubular structures and in discrete nuclear dots resembling ND10 nuclear bodies. May shuttle between nucleus and cytoplasm.
Tissue Specificity	Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.
Top Pathways	Ubiquitin mediated proteolysis, Primary immunodeficiency

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human AIRE peptide - ab92688 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human AIRE peptide - ab23217 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

AIRE Antibody Blocking Peptide - LS-E725 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIRE Antibody Blocking Peptide - LS-E25382 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIRE Antibody Blocking Peptide - LS-E11469 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIRE Antibody Blocking Peptide - LS-E11161 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIRE Antibody Blocking Peptide - LS-E26245 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIRE Antibody Blocking Peptide - LS-E26107 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIRE Antibody Blocking Peptide - LS-E13625 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIRE-Antibody-Center-Blocking-peptide - BP11079c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AIRE (isoform 1) blocking peptide - GTX89336-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Rat, Bovine

AIRE (isoforms 1 + 2) blocking peptide - GTX89216-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

AIRE (isoforms 1 and 2) blocking peptide - GTX13573-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

AIRE Immunizing peptide - orb17592 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Goat anti AIRE antibody Immunizing peptide - orb16444 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

AIRE Blocking Peptide - abx062024 from Abbexa Category Peptide Species Human, Mouse, Rat

AIRE Peptide - AC21-0210-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

AIRE Peptide - AC21-0935-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

AIRE Peptide - AC21-1077-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

AIRE Peptide - 45-226P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

AIRE Peptide - 45-227P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

AIRE Peptide - 45-225P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

AIRE fusion protein - ag18249 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

AIRE fusion protein - ag19103 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human AIRE, His-tagged - AIRE-3784H from Creative Biomart Category Protein Source E. Coli or Yeast Species Human

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