MGAT3
| Gene Symbol | MGAT3 |
|---|---|
| Entrez Gene | 4248 |
| Alt Symbol | GNT-III, GNT3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase |
| Other Description | GlcNAc-T III|N-acetylglucosaminyltransferase III|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III|beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
| Swissprots | Q9UH32 A6NGD0 Q14CK5 Q09327 Q6IC49 |
| Accessions | BAA19868 EAW60332 Q09327 AK125361 AK313664 BAG36416 BC075025 AAH75025 BC075026 AAH75026 BC113383 AAI13384 BC113718 AAI13719 BG683192 BM675328 CR456519 CAG30405 CU013119 CAK54550 CU013407 CAK54849 D13789 BAA02937 DA261678 DA370485 DA519457 HQ258450 ADR83204 L48489 XM_005261608 XP_005261665 XM_005261609 XP_005261666 XM_006724252 XP_006724315 XM_011530184 XP_011528486 XM_011530185 XP_011528487 XM_011530186 XP_011528488 XM_011530187 XP_011528489 XM_011530188 XP_011528490 XM_011530189 XP_011528491 XM_011530190 XP_011528492 XM_011530191 XP_011528493 XM_011530192 XP_011528494 XM_011530193 XP_011528495 XM_011530194 XP_011528496 NM_001098270 NP_001091740 NM_002409 NP_002400 |
| Function | It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. |
| Subcellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. |
| Top Pathways | N-Glycan biosynthesis |
GnT-III CRISPR/Cas9 KO Plasmid (h) - sc-407172 from Santa Cruz Biotechnology
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GnT-III HDR Plasmid (h) - sc-407172-HDR from Santa Cruz Biotechnology
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GnT-III Double Nickase Plasmid (h) - sc-407172-NIC from Santa Cruz Biotechnology
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GnT-III Double Nickase Plasmid (h2) - sc-407172-NIC-2 from Santa Cruz Biotechnology
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GnT-III CRISPR Activation Plasmid (h) - sc-407172-ACT from Santa Cruz Biotechnology
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GnT-III CRISPR Activation Plasmid (h2) - sc-407172-ACT-2 from Santa Cruz Biotechnology
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GnT-III Lentiviral Activation Particles (h) - sc-407172-LAC from Santa Cruz Biotechnology
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GnT-III Lentiviral Activation Particles (h2) - sc-407172-LAC-2 from Santa Cruz Biotechnology
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GnT-III siRNA (h) - sc-43808 from Santa Cruz Biotechnology
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GnT-III shRNA Plasmid (h) - sc-43808-SH from Santa Cruz Biotechnology
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GnT-III shRNA (h) Lentiviral Particles - sc-43808-V from Santa Cruz Biotechnology
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N-Acetylglucosaminyltransferase III/MGAT3 RNAi - H00004248-R01 from Novus Biologicals
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N-Acetylglucosaminyltransferase III/MGAT3 RNAi - H00004248-R02 from Novus Biologicals
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MISSION® esiRNA - EHU138911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13274 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13274 from Sigma-Aldrich
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MGAT3 siRNA (Human) - CRH2888 from Cohesion Biosciences
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shRNA set against Human MGAT3 (NM_002409.4) - SHH341363 from Creative biogene
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shRNA set against Human MGAT3(NM_002409.4) - SHH187301 from Creative biogene
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Human MGAT3 siRNA - orb263390 from Biorbyt
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MGAT3 shRNA Plasmid (Human) - CHH2888 from Cohesion Biosciences
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MGAT3 miRNA 3'UTR clone - MiUTR1H-06243 from Creative biogene
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