SMC1

Gene Symbol SMC1
Entrez Gene 850540
Alt Symbol CHL10
Species Yeast
Gene Type protein-coding
Description cohesin subunit SMC1
Other Description -
Swissprots P32908 D6VTM2
Accessions DAA12432 P32908 NM_001179958 NP_116647
Function Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
Subcellular Location Nucleus. Chromosome. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. At anaphase, the MCD1 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Top Pathways Cell cycle - yeast, Meiosis - yeast