| Gene Symbol |
SMC1
|
| Entrez Gene |
850540
|
| Alt Symbol |
CHL10
|
| Species |
Yeast
|
| Gene Type |
protein-coding
|
| Description |
cohesin subunit SMC1
|
| Other Description |
-
|
| Swissprots |
P32908 D6VTM2
|
| Accessions |
DAA12432 P32908 NM_001179958 NP_116647
|
| Function |
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
|
| Subcellular Location |
Nucleus. Chromosome. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. At anaphase, the MCD1 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
|
| Top Pathways |
Cell cycle - yeast, Meiosis - yeast
|