| Gene Symbol |
TOP3A
|
| Entrez Gene |
7156
|
| Alt Symbol |
TOP3, ZGRF7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
topoisomerase (DNA) III alpha
|
| Other Description |
DNA topoisomerase 3-alpha|DNA topoisomerase III alpha|topo III-alpha|zinc finger, GRF-type containing 7
|
| Swissprots |
Q13472 Q13473 A8KA61 D3DXC7 B4DK80
|
| Accessions |
ADP90454 ADP90455 ADP90456 ADP90457 ADP90458 ADP90459 ADP90460 ADP90461 ADP90462 ADP90463 ADP90464 ADP90465 ADP90466 ADP90467 ADP90468 ADP90469 ADP90470 ADP90471 ADP90472 ADP90473 ADP90474 ADP90475 ADP90476 ADP90477 ADP90478 ADP90479 ADP90480 ADP90481 ADP90482 ADP90483 ADP90484 ADP90485 ADP90486 ADP90487 ADP90488 ADP90489 ADP90490 ADP90491 ADP90492 ADP90493 EAW55646 EAW55647 EAW55648 EAW55649 Q13472 AF086042 AK126869 BAG54385 AK290513 BAF83202 AK292926 BAF85615 AK296437 BAG59092 AK299764 BAG61652 AK311668 BC051748 AAH51748 BM462184 U43431 AAB03694 XM_005256776 XP_005256833 XM_011524000 XP_011522302 XM_011524001 XP_011522303 NM_004618 NP_004609
|
| Function |
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity. {ECO:0000269|PubMed:20445207, ECO:0000269|PubMed:8622991}.
|
| Tissue Specificity |
High expression is found in testis, heart, skeletal muscle and pancreas.
|
| Top Pathways |
Homologous recombination, Fanconi anemia pathway
|