ABCC11

Gene Symbol	ABCC11
Entrez Gene	85320
Alt Symbol	EWWD, MRP8, WW
Species	Human
Gene Type	protein-coding
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Other Description	ATP-binding cassette protein C11|ATP-binding cassette sub-family C member 11|ATP-binding cassette transporter MRP8|ATP-binding cassette transporter sub-family C member 11|multi-resistance protein 8|multidrug resistance-associated protein 8
Swissprots	Q9BX80 Q96JA6 Q96J66 Q8TDJ0
Accessions	EAW82715 EAW82716 EAW82717 EAW82718 EAW82719 EAW82720 EAW82721 EAW82722 Q96J66 AF352582 AAK19755 AF367202 AAK58869 AF411579 AAL99902 AK301547 BAG63044 AL117406 AY040219 AAK76739 BC039085 BC152902 AAI52903 BC157084 AAI57085 XM_011523396 XP_011521698 XM_011523397 XP_011521699 XM_011523398 XP_011521700 NM_032583 NP_115972 NM_033151 NP_149163 NM_145186 NP_660187
Function	Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax. {ECO:0000269|PubMed:12764137, ECO:0000269|PubMed:15537867, ECO:0000269|PubMed:16444273}.
Subcellular Location	Membrane; Multi-pass membrane protein.
Tissue Specificity	Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta. {ECO:0000269|PubMed:11483364, ECO:0000269|PubMed:11591886}.
Top Pathways	ABC transporters

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ABCC11 full length protein - ab164740 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human ABCC11 protein fragment - ab164741 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

ABCC11 / MRP8 Antibody Blocking Peptide - LS-E16079 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ABCC11 / MRP8 Antibody Blocking Peptide - LS-E7591 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ABCC11 / MRP8 Antibody Blocking Peptide - LS-E26781 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ABCC11 Protein - H00085320-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ABCC11 Protein - H00085320-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

ABCC11-Antibody-N-term-Blocking-Peptide - BP4787a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ABCC11 Blocking Peptide - 33R-6880 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ABCC11 Blocking Peptide - abx064020 from Abbexa Category Peptide Species Human, Mouse, Rat

ABCC11 Peptide - AC21-1613-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ABCC11 / MRP8 - H00085320-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

ABCC11 / MRP8 - H00085320-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ABCC11 / MRP8 - H00085320-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MRP8 Peptide - 46-868P from ProSci Category Peptide Species Human

ABCC11 fusion protein - ag4050 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant ATP Binding Cassette Transporter C11 (ABCC11) - RPD631Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

ABCC11 Blocking Peptide - CBP2826 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

ABCC11 Protein - abx163754 from Abbexa Category Protein Species Human

MRP8/ABCC11, Peptide - MBS426375 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog

ABCC11 Recombinant Protein Antigen - NBP2-38193PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ABCC11 Protein - NBP2-38192PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ABCC11 Recombinant Protein Antigen - NBP1-82623PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E.coli Species Human

ABCC11 Peptide, Human - M34GP00051H from Creative Peptides Category Peptide Source Synthetic. Species Human

ABCC11 Recombinant Protein (OPCD00788) - OPCD00788 from Aviva Systems Biology Category Protein Source E.coli Species Human

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