PCSK1N

Gene Symbol	PCSK1N
Entrez Gene	27344
Alt Symbol	PROSAAS, SAAS, SCG8, SgVIII
Species	Human
Gene Type	protein-coding
Description	proprotein convertase subtilisin/kexin type 1 inhibitor
Other Description	granin-like neuroendocrine peptide|pro-SAAS|proSAAS|proprotein convertase 1 inhibitor
Swissprots	Q9UHG2 Q4VC04
Accessions	EAW50742 Q9UHG2 AA706516 AF181562 AAF22643 BC002851 AAH02851 BC094731 BX459856 DQ893525 ABM84451 HY114016 HY348068 NM_013271 NP_037403
Function	May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity). {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Guam disease). {ECO:0000269|PubMed:12914799, ECO:0000269|PubMed:14746899}.
Tissue Specificity	Expressed in brain and pancreas. {ECO:0000269|PubMed:10632593}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ProSAAS full length protein - ab174456 from Abcam Category Protein Source E. coli Species Human

Human ProSAAS protein fragment - ab162149 from Abcam Category Protein Source Wheat germ Species Human

PCSK1N / PROSAAS Antibody Blocking Peptide - LS-E21655 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PCSK1N Partial Recombinant Protein - H00027344-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PCSK1N Protein - NBP2-23370 from Novus Biologicals Category Protein Prices $269.00 Sizes 20 µg Source E.coli Species Human

PCSK1N protein (His tag) - 80R-3621 from Fitzgerald Category Protein Prices $275.00 Sizes 20 µg Source E.coli

PCSK1N (34-260, His-tag) - AR51308PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

PCSK1N (34-260, His-tag) - AR51308PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

PCSK1N - H00027344-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PCSK1N - H00027344-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PCSK1N, 34-260aa, Human, His tag, E.coli - 01-P2488 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

PCSK1N, 34-260aa, Human, His tag, E.coli - GWB-LD595C from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 20 μg, 100 μg Species Human

Recombinant human PCSK1N, His-tagged - PCSK1N-2488H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human ProSAAS(PCSK1N) - CSB-YP890694HU CSB-EP890694HU CSB-BP890694HU CSB-MP890694HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PCSK1N, 34-260aa, Human, His tag, E.coli (Denatured) - ATGP2488 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 4 µg, 20 µg, 100 µg Species Human

Proprotein Convertase Subtilisin/Kexin Type 1 Inhibitor Protein (Recombinant) - abx263400 from Abbexa Category Protein

PCSK1N - TP301065 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PCSK1N, Recombinant Protein - MBS204985 from MyBioSource Category Protein Prices $310.00, $720.00 Sizes 20 µg, 100 µg Source E Coli Species Human

Proprotein Convertase Subtilisin/Kexin Type 1 Inhibitor, Recombinant Protein - MBS145968 from MyBioSource Category Protein Prices $140.00, $205.00, $1,220.00 Sizes 2 µg, 10 µg, 100 µg

ProSAAS (PCSK1N), Recombinant Protein - MBS1307611 from MyBioSource Category Protein Prices $980.00, $980.00, $1,205.00, $1,205.00, $1,465.00, $1,465.00, $1,925.00, $1,925.00, $1,925.00, $2,885.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

proSAAS, Peptide - MBS428625 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

PCSK1N Recombinant Protein Antigen - NBP1-80797PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Human PCSK1N protein - orb260004 from Biorbyt Category Protein Prices $170.00, $289.00, $1,122.00 Sizes 2 μg, 10 μg, 100 μg Species Human

PCSK1N Recombinant Protein Antigen - NBP2-49423PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

PCSK1N Peptide, Human - M34GP11465H from Creative Peptides Category Peptide Source Synthetic. Species Human

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