IL4

Gene Symbol IL4
Entrez Gene 3565
Alt Symbol BCGF-1, BCGF1, BSF-1, BSF1, IL-4
Species Human
Gene Type protein-coding
Description interleukin 4
Other Description B cell growth factor 1|B_cell stimulatory factor 1|binetrakin|interleukin 4 variant 2|interleukin-4|lymphocyte stimulatory factor 1|pitrakinra
Swissprots Q14630 Q6NZ77 P05112
Accessions AAA59150 AAK71324 ADD60204 ADN03408 ADN03409 ADN03410 ADN03411 ADN03412 ADN03413 ADN03414 ADN03415 ADN03416 ADN03417 ADN03418 ADN03419 ADN03420 ADN03421 ADN03422 ADN03423 CAA29925 CAJ75955 CAV32874 CBL86566 CBX32734 EAW62322 EAW62323 P05112 AB102862 BAD89396 AF043336 AAC03537 AM937235 CAP72493 BC066277 AAH66277 BC066278 BC067514 AAH67514 BC067515 AAH67515 BC070123 AAH70123 CD640452 EF173851 ABM53124 JX878389 AGM38212 M13982 AAA59149 X81851 CAA57444 NM_000589 NP_000580 NM_172348 NP_758858
Function Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
Subcellular Location Secreted.
Top Pathways Inflammatory bowel disease (IBD), Measles, PI3K-Akt signaling pathway, Leishmaniasis, Cytokine-cytokine receptor interaction

IL-4 (D19A10) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 13425 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D19A10
Flow cytometric analysis of human peripheral blood mononuclear cells, untreated (left) or treated (right) with TPA #4174 (40 nM, 5 hr), Ionomycin, Calcium Salt #9995 (2 μM, 5 hr), and Brefeldin A #9972 (3 μg/ml, last 4 hr of stimulation), using a CD3-PE antibody and IL-4 (D19A10) Rabbit mAb (Alexa Fluor ® 647 Conjugate). Analysis was performed on cells in the lymphocyte gate.

IL-4 (D19A10) Rabbit mAb (PE Conjugate) - 12884 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D19A10
Flow cytometric analysis of human peripheral blood mononuclear cells, untreated (left) or treated (right) with TPA #4174 (40 nM, 5 hr), Ionomycin, Calcium Salt #9995 (2 μM, 5 hr), and Brefeldin A #9972 (3 μg/ml, last 4 hr of stimulation), using a CD3-APC antibody and IL-4 (D19A10) Rabbit mAb (PE Conjugate). Analysis was performed on cells in the lymphocyte gate.

IL-4 (D19A10) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 13351 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D19A10
Flow cytometric analysis of human peripheral blood mononuclear cells, untreated (left) or treated (right) with TPA #4174 (40 nM, 5 hr), Ionomycin, Calcium Salt #9995 (2 μM, 5 hr), and Brefeldin A #9972 (3 μg/ml, last 4 hr of stimulation), using a CD3-APC antibody and IL-4 (D19A10) Rabbit mAb (Alexa Fluor ® 488 Conjugate). Analysis was performed on cells in the lymphocyte gate.

Human IL-4 Neutralizing (D20H1) Rabbit mAb - 11964 from Cell Signaling Technology

Prices $338.00
Sizes 100 µg
Host Rabbit
Clonality Monoclonal
Clone D20H1
The proliferation of TF-1 cells treated with increasing concentrations of hIL-4 #8919 was assessed. After 72 hr, cells were incubated with a tetrazolium salt and the OD 450 was determined.

IL-4 (D19A10) Rabbit mAb - 12227 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D19A10
Western blot analysis of extracts from purified CD4 + human peripheral blood mononuclear cells, activated with anti-CD3 and anti-CD28 in Th2-inducing conditions for 12 d, untreated (-) or treated (+) with TPA #4174 (40 nM, 6 hr), Ionomycin #9995 (3 μM, 6 hr), and Brefeldin A #9972 (300 ng/ml, last 5 hr of stimulation), using IL-4 (D19A10) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

IL-4 (M-19) - sc-1261 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of mouse recombinant IL-4 (A,B). Antibodies tested include IL-4 (C-19): sc-1260 (A) and IL-4 (M-19): sc-1261 (B).

IL-4 (H-129) - sc-7919 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-4 (H-129): sc-7919. Western blot analysis of human recombinant IL-4.

IL-4 (HIL41) - sc-12723 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of human recombinant IL-4. Antibodies tested include IL-4 (HIL41): sc-12723 (A) and IL-4 (HIL44): sc-13555 (B).

IL-4 (HIL44) - sc-13555 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-4 (HIL44): sc-13555. Western blot analysis of human recombinant IL-4 fusion protein (A,B).

IL-4 (8D4-8) - sc-53710 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-IL4 antibody - ab9622 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab9622 staining IL4 in human breast invasive ductal carcinoma section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent heat mediated antigen retrieval in sodium citrate buffer (pH 6.0). The primary antibody was used at 0.25 ug/ml and incubated with sample at 4°C overnight. A HRP-labeled polymer detection system was used with a DAB chromogen. Additional protein blocks were used in conjuction with secondary reagents.

Anti-IL4 antibody - ab126870 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL4 antibody - ab89974 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IL4 antibody (ab89974) at 1 µg/ml + Fetal spleen lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-IL4 antibody - ab9323 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal

Anti-IL4 antibody - ab10755 from Abcam

Prices $370.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-IL4 antibody - ab157745 from Abcam

Host Sheep
Clonality Polyclonal

Anti-IL4 antibody [11-60] - ab38153 from Abcam

Prices $370.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 11-60

Anti-IL4 antibody [11-60] (HRP) - ab10107 from Abcam

Prices $370.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 11-60

Anti-IL4 antibody [5B5] - ab25033 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5B5

Anti-IL4 antibody [8D4-8] (Allophycocyanin) - ab95716 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8D4-8

Anti-IL4 antibody [8D4-8] (Phycoerythrin) - ab95717 from Abcam

Prices $376.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 8D4-8
Normal human peripheral blood cells stimulated with PMA and Ionomycin in the presence of brefeldin A for 6 hours. The cells were surface stained with Anti-Human CD3 FITC and intracellularly stained with ab95717 (right panel). Left panel demonstrates unlabelled antibody blocking control.

Anti-IL4 antibody [B-G28] (Phycoerythrin) - ab27358 from Abcam

Prices $370.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone B-G28

Anti-IL4 antibody [B-S4] - ab47196 from Abcam

Prices $368.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone B-S4

Anti-IL4 antibody (Biotin) - ab84242 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-IL4 antibody (Biotin) - ab106142 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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