| Gene Symbol | GSTA3 |
|---|---|
| Entrez Gene | 2940 |
| Alt Symbol | GSTA3-3, GTA3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutathione S-transferase alpha 3 |
| Other Description | GST class-alpha member 3|S-(hydroxyalkyl)glutathione lyase A3|glutathione S-alkyltransferase A3|glutathione S-aralkyltransferase A3|glutathione S-aryltransferase A3|glutathione S-transferase A3|glutathione S-transferase A3-3 |
| Swissprots | Q9H415 Q16772 Q068V6 Q8WWA8 O43468 |
| Accessions | AAA74634 ABI75350 EAX04390 EAX04391 Q16772 AA846513 AF020919 AAD04712 AF508266 AAM33360 AI199811 BC020619 AAH20619 BG573805 DQ891389 ABM82315 DQ894564 ABM85490 DT932587 XM_006715072 XP_006715135 XM_011514533 XP_011512835 XR_926166 XR_926167 NM_000847 NP_000838 |
| Function | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)- pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. {ECO:0000269|PubMed:15595823, ECO:0000269|PubMed:20083122}. |
| Subcellular Location | Cytoplasm. |
| Top Pathways | Chemical carcinogenesis, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450 |