TXNRD1

Gene Symbol TXNRD1
Entrez Gene 7296
Alt Symbol GRIM-12, TR, TR1, TRXR1, TXNR
Species Human
Gene Type protein-coding
Description thioredoxin reductase 1
Other Description KM-102-derived reductase-like factor|gene associated with retinoic and IFN-induced mortality 12 protein|gene associated with retinoic and interferon-induced mortality 12 protein|oxidoreductase|thioredoxin reductase 1, cytoplasmic|thioredoxin reductase GRIM-12|thioredoxin reductase TR1
Swissprots E9PMY9 Q6VBP9 Q6VBP2 Q6FI31 Q76P53 Q99475 Q6YNQ1 Q8WVC8 B7Z904 Q16881 Q9UH79 Q9UES8 Q6VB41 Q6VB40 Q6VBQ0 B7Z1F4 Q6VB42 B7Z3Y8 Q7LA96 F5H780 Q6VBP4 Q6VBP5 Q6VBP3
Accessions AAZ67916 EAW97743 EAW97744 EAW97745 Q16881 AF077367 AAC69621 AF208018 AAF15900 AI097548 AJ001050 CAA04503 AK128515 BAC87474 AK129977 AK226071 AK293322 BAH11490 AK295067 BAH11961 AK296495 BAH12374 AK304241 BAH14140 AK308881 AK312262 BAG35193 AL701549 AY057105 AAL15432 AY344070 AY344071 AY344072 AY344074 AY344077 AY344080 AY344081 AAQ62461 AY344083 AAQ62462 AY344084 AAQ62463 AY344086 AAQ62464 AY344087 AAQ62465 AY344088 AY344089 AAQ62466 AY344092 AAQ62467 AY344093 AAQ62468 AY344095 AAQ62469 AY344096 AAQ62470 AY344669 AY344670 AAQ62471 AY344671 AY344672 AY344673 AAQ62472 AY344675 AY344679 AAQ62473 AY423378 BC018122 AAH18122 BC042974 BG772375 BT019640 AAV38446 CR536506 CAG38744 D88687 BAA13674 DA238692 DA319870 DA440625 DC351122 DC400503 DC401138 DC418649 S79851 AAB35418 X91247 CAA62629 NM_001093771 NP_001087240 NM_001261445 NP_001248374 NM_001261446 NP_001248375 NM_003330 NP_003321 NM_182729 NP_877393 NM_182742 NP_877419 NM_182743 NP_877420
Function Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid. {ECO:0000269|PubMed:15199063, ECO:0000269|PubMed:18042542, ECO:0000269|PubMed:8577704, ECO:0000269|PubMed:9774665}.
Subcellular Location Isoform 5: Cytoplasm.
Tissue Specificity Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver. {ECO:0000269|PubMed:18042542, ECO:0000269|PubMed:8999974}.
Top Pathways Selenocompound metabolism, Pyrimidine metabolism

Thioredoxin Reductase 1 (TXNRD1) Human SimpleStep ELISA™ Kit - ab192150 from Abcam

Category ELISA Kit
Prices $470.00
Sizes 1 x 96 tests
Sensitivity 0.16 ng/ml
Range 0.4 ng/ml - 24 ng/ml
Background-subtracted data values (mean +/- SD) are graphed.

Thioredoxin Reductase 1 (TXNRD1) Activity Assay Kit - ab190804 from Abcam

Category Cellular Assay
Prices $435.00
Sizes 1 x 96 tests
Range 5 µg/ml - 1000 µg/ml
The data shown above was collected at the endpoint after 30 minutes.

Thioredoxin Reductase Colorimetric Assay Kit - KA0883 from Novus Biologicals

Category Assay Kit
Prices $599.00
Sizes 1 kit

Human TRXR1 / TXNRD1 ELISA Kit (Sandwich ELISA) - LS-F4706 from LifeSpan Bioscience

Category ELISA Kit
Prices $650.00
Sizes 1 plate
Sensitivity 0.131 ng/ml
Range 0.313-20 ng/ml

Mouse TRXR1 / TXNRD1 ELISA Kit (Sandwich ELISA) - LS-F4707 from LifeSpan Bioscience

Category ELISA Kit
Prices $670.00
Sizes 1 plate
Sensitivity 15.63 pg/ml
Range 0.313-20 ng/ml

Human TRXR1 / TXNRD1 ELISA Kit (Sandwich ELISA) - LS-F12859 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.312
Range 0.313-20 ng/ml

TR1 ELISA kit - 55R-1874 from Fitzgerald

Category ELISA Kit
Prices $495.00
Sizes 1 kit

Thioredoxin Reductase 1 (TrxR1), Human, ELISA Kit - SEA703Hu from ARP American Research Products

Category ELISA Kit
Prices $650.00
Sizes 96 t
Sensitivity 0.123ng/mL
Range 0.312-20ng/mL

Thioredoxin reductase 1, cytoplasmic, TXNRD1, Human, ELISA Kit - E1507h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 0.312-20 ng/mL

Thioredoxin reductase, TrxR, Human, ELISA Kit - CSB-E09731h from ARP American Research Products

Category ELISA Kit
Prices $450.00, $595.00, $596.00, $599.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 0.078ng/ml
Range 0.312 ng/ml-20 ng/ml

Thioredoxin Reductase 1, TrxR1, Human, ELISA Kit - E-EL-H1728 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t
Sensitivity 0.094
Range 0.156-10ng/mL

Thioredoxin Reductase 1, TrxR1, Rabbit, ELISA Kit - E-EL-RB1470 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Thioredoxin Reductase 1, TrxR1, Chicken, ELISA Kit - E-EL-Ch0260 from ARP American Research Products

Category ELISA Kit
Prices $445.50
Sizes 96 t
Sensitivity 0.094
Range 0.156-10ng/mL

Thioredoxin Reductase 1, TrxR1, Porcine, ELISA Kit - E-EL-P1290 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Thioredoxin Reductase 1, TrxR1, Sheep, ELISA Kit - E-EL-S0020 from ARP American Research Products

Category ELISA Kit
Prices $648.00
Sizes 96 t

Thioredoxin Reductase 1, TrxR1, Guinea Pig, ELISA Kit - E-EL-GP1047 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

Thioredoxin Reductase 1, TrxR1, Monkey, ELISA Kit - E-EL-MK0532 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Thioredoxin Reductase 1 (TrxR1), Human, CLIA Kit - SCA703Hu from ARP American Research Products

Category CLIA Kit
Prices $840.00
Sizes 96 t
Sensitivity 12.5pg/mL
Range 41.2-30,000pg/mL.

TXNRD1 (Human) ELISA kit - KA0534 from Acris Antibodies

Category ELISA Kit
Prices $650.00
Sizes 1 kit

TR, ELISA Kit - MBS2502189 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 9.375ng/mL
Range 15.625-1000ng/mL

TR, ELISA Kit - MBS2506644 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 9.375ng/mL
Range 15.625-1000ng/mL

TR, ELISA Kit - MBS2505387 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.938ng/mL
Range 1.563-100ng/mL

TR, ELISA Kit - MBS2507446 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

TR, ELISA Kit - MBS2509527 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.938ng/mL
Range 1.563-100ng/mL

TR, ELISA Kit - MBS2500592 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.875ng/mL
Range 3.125-200ng/mL
Search more