| Gene Symbol | EXO1 |
|---|---|
| Entrez Gene | 9156 |
| Alt Symbol | HEX1, hExoI |
| Species | Human |
| Gene Type | protein-coding |
| Description | exonuclease 1 |
| Other Description | hExo1|rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1 |
| Swissprots | Q9UQ84 Q96IJ1 Q9UG38 O75214 O60545 Q5T396 O75466 Q9UNW0 |
| Accessions | AAC32424 AAC69879 AAC69880 AAN39382 EAW70103 EAW70104 EAW70105 EAW70106 Q9UQ84 AF042282 AAC32259 AF060479 AAC33874 AF084974 AAD13754 AF091740 AAC63043 AK291291 BAF83980 AL080139 CAB45733 BC007491 AAH07491 BM465399 BM983504 CA430743 CD644038 CN348533 DA661516 DQ893032 ABM83958 EU176754 ABW03555 XM_005273350 XP_005273407 XM_006711840 XP_006711903 XM_011544321 XP_011542623 XM_011544322 XP_011542624 XM_011544323 XP_011542625 XM_011544324 XP_011542626 XM_011544325 XP_011542627 XM_011544326 XP_011542628 XM_011544327 XP_011542629 XR_949162 NM_003686 NP_003677 NM_006027 NP_006018 NM_130398 NP_569082 |
| Function | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:11429708, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:17426132}. Note=Colocalizes with PCNA to discrete nuclear foci in S-phase. |
| Tissue Specificity | Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach. {ECO:0000269|PubMed:10856833, ECO:0000269|PubMed:9685493, ECO:0000269|PubMed:9788596, ECO:0000269|PubMed:9823303}. |
| Top Pathways | Mismatch repair |