EXO1

Gene Symbol	EXO1
Entrez Gene	9156
Alt Symbol	HEX1, hExoI
Species	Human
Gene Type	protein-coding
Description	exonuclease 1
Other Description	hExo1|rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
Swissprots	Q9UQ84 Q96IJ1 Q9UG38 O75214 O60545 Q5T396 O75466 Q9UNW0
Accessions	AAC32424 AAC69879 AAC69880 AAN39382 EAW70103 EAW70104 EAW70105 EAW70106 Q9UQ84 AF042282 AAC32259 AF060479 AAC33874 AF084974 AAD13754 AF091740 AAC63043 AK291291 BAF83980 AL080139 CAB45733 BC007491 AAH07491 BM465399 BM983504 CA430743 CD644038 CN348533 DA661516 DQ893032 ABM83958 EU176754 ABW03555 XM_005273350 XP_005273407 XM_006711840 XP_006711903 XM_011544321 XP_011542623 XM_011544322 XP_011542624 XM_011544323 XP_011542625 XM_011544324 XP_011542626 XM_011544325 XP_011542627 XM_011544326 XP_011542628 XM_011544327 XP_011542629 XR_949162 NM_003686 NP_003677 NM_006027 NP_006018 NM_130398 NP_569082
Function	5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:11429708, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:17426132}. Note=Colocalizes with PCNA to discrete nuclear foci in S-phase.
Tissue Specificity	Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach. {ECO:0000269|PubMed:10856833, ECO:0000269|PubMed:9685493, ECO:0000269|PubMed:9788596, ECO:0000269|PubMed:9823303}.
Top Pathways	Mismatch repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Exonuclease 1 protein fragment - ab152957 from Abcam Category Protein Source Wheat germ Species Human

EXO1 Antibody Blocking Peptide - LS-E7167 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EXO1 Antibody Blocking Peptide - LS-E23155 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EXO1 Antibody Blocking Peptide - LS-E23156 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EXO1 Antibody Blocking Peptide - LS-E26598 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Exonuclease 1 Partial Recombinant Protein - H00009156-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EXO1-Antibody-N-term-Blocking-Peptide - BP2871a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Exonuclease 1 blocking peptide - GTX88837-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

EXO1 Blocking Peptide - abx063557 from Abbexa Category Peptide Species Human, Mouse

Exonuclease 1 Peptide - AC21-1434-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Exonuclease 1 (EXO1) - H00009156-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Exonuclease 1 (EXO1) - H00009156-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EXO1 Peptide - 45-556P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

EXO1 fusion protein - ag9253 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

EXO1 Blocking Peptide - CBP2363 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

Exo1 (K86) Peptide - BS2536P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Exonuclease 1(EXO1) ,partial - CSB-YP007876HU CSB-EP007876HU CSB-BP007876HU CSB-MP007876HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EXO1 Protein - abx163012 from Abbexa Category Protein Species Human

EXO1, Peptide - MBS425309 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Exonuclease 1 (EXO1) - RPC467Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Exonuclease 1 (EXO1) - RPC467Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Exonuclease 1 (EXO1) - RPC467Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Exonuclease 1 (EXO1) - RPC467Hu01 from Cloud-clone Category Protein Source E.coli Species Human

EXO1 Peptide, Human - M34GP05125H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Exonuclease 1 (EXO1) - RPU51952 from Biomatik Category Protein Prices $183.00, $374.00, $572.00, $682.24 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

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