CSNK2A1

Gene Symbol CSNK2A1
Entrez Gene 1457
Alt Symbol CK2A1, CKII, CSNK2A3
Species Human
Gene Type protein-coding
Description casein kinase 2, alpha 1 polypeptide
Other Description CK II alpha 3|CK2 catalytic subunit alpha|casein kinase II alpha 1 polypeptide pseudogene|casein kinase II alpha 1 subunit|casein kinase II subunit alpha|protein kinase CK2
Swissprots P20426 D3DVV8 P19138 Q14013 Q5U065 P68400 B4DYS6
Accessions EAX10665 EAX10666 EAX10667 EAX10668 EAX10669 P68400 Q8NEV1 AB451279 BAG70093 AB451411 BAG70225 AK302583 BAG63838 AK312535 BAG35434 AU130091 AU131227 AU132198 AU133318 AW876962 AY735339 BC002615 BC011668 AAH11668 BC050036 AAH50036 BC053532 AAH53532 BC071167 AAH71167 BT019792 AAV38595 DQ354583 ABC86794 DQ893102 ABM84028 DQ896374 ABM87373 J02853 AAA56821 M55265 AAA35503 S53149 ABB72474 XM_011529175 XP_011527477 XM_011529176 XP_011527478 NM_001895 NP_001886 NM_177559 NP_808227 NM_177560 NP_808228
Function Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activat
Top Pathways Wnt signaling pathway, Adherens junction, Tight junction, Ribosome biogenesis in eukaryotes, Measles

CK2α Antibody - 2656 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from various cell lines using CK2α Antibody.

casein kinase IIα (D-10) - sc-365762 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
casein kinase IIα (D-10): sc-365762. Western blot analysis of casein kinase IIα expression in HeLa (A), NIH/3T3 (B) and Jurkat (C) whole cell lysates.

casein kinase IIα (C-18) - sc-6479 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
casein kinase IIα (C-18): sc-6479. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic staining.

casein kinase IIα (E-2) - sc-365787 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
casein kinase IIα (E-2): sc-365787. Western blot analysis of casein kinase IIα expression in HeLa whole cell lysate.

casein kinase IIα (E-7) - sc-373894 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
casein kinase IIα (E-7): sc-373894. Western blot analysis of casein kinase IIα expression in HeLa (A) and NIH/3T3 (B) whole cell lysates.

casein kinase IIα (H-286) - sc-9030 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
casein kinase IIα (H-286): sc-9030. Western blot analysis of casein kinase IIα expression in non-transfected: sc-117752 (A) and mouse casein kinase IIα transfected: sc-126578 (B) 293T whole cell lysates.

casein kinase IIα (N-18) - sc-6480 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
casein kinase IIα (N-18): sc-6480. Western blot analysis of casein kinase IIα expression in K-562 (A) and BJAB (B) whole cell lysates.

casein kinase IIα (1AD9) - sc-12738 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
casein kinase IIα (1AD9): sc-12738. Western blot analysis of casein kinase IIα expression in non-transfected: sc-117752 (A) and mouse casein kinase IIα transfected: sc-126578 (B) 293T whole cell lysates.

casein kinase IIα (F-10) - sc-365763 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
casein kinase IIα (F-10): sc-365763. Western blot analysis of casein kinase IIα expression in HeLa (A), NIH/3T3 (B) and Jurkat (C) whole cell lysates.

Anti-CKII alpha (phospho T360 + S362) antibody - ab119410 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CKII alpha (phospho T360 + S362) antibody (ab119410) at 1/1000 dilutionLane 1 : CKII alphaLane 2 : CKII alpha + ERK2Lane 3 : CKII alpha T360ALane 4 : CKII alpha T360A + ERK2Lane 5 : CKII alpha S362ALane 6 : CKII alpha S362A + ERK2Lane 7 : CKII alpha T360/S362ALane 8 : CKII alpha T360/S362A + ERK2

Anti-CKII alpha (phospho Y255) antibody - ab64950 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CKII alpha (phospho Y255) antibody (ab64950) at 1/500 dilutionLane 1 : HeLa cell extractLane 2 : Jurkat cell extractLane 3 : Jurkat cell extract with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-CKII alpha antibody - ab13410 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CKII alpha antibody - ab150484 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Immunohistochemical analysis of paraffin embedded Human testis tissue labelling CKII alpha with ab150484 antibody at a dilution of 1/200.

Anti-CKII alpha antibody - ab118623 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-CKII alpha antibody (ab118623) at 1/500 dilution + Jurkat cell lysate

Anti-CKII alpha antibody [3G1] - ab78897 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G1
Anti-CKII alpha antibody [3G1] (ab78897) at 1/1000 dilution + HeLa cell lysate at 30 µgSecondarygoat anti-mouse HRPdeveloped using the ECL technique

Anti-CKII alpha antibody [EP1963Y] - ab76040 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1963Y
Overlay histogram showing Jurkat cells stained with ab76040 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab76040, 1/50 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-CSNK2A1 Antibody (aa7-22) - LS-C21275 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK2A1 Antibody (aa319-324) - LS-C21280 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CSNK2A1 Antibody (aa1-34) - LS-C77829 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK2A1 Antibody (aa354-391) - LS-C77831 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK2A1 Antibody (aa276-335) - LS-C77830 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK2A1 Antibody - LS-C77832 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK2A1 Antibody - LS-C83018 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK2A1 Antibody - LS-C43055 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of human CKII alpha in a RIPA extract of Hela cells treated with either CKII alpha siRNA (a) or vimentin SiRNA (v) by Western blotting with Rabbit anti-Human CKII alpha (LS-C43055).

Anti-CSNK2A1 Antibody - LS-C83017 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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