PAN2

Gene Symbol PAN2
Entrez Gene 9924
Alt Symbol USP52
Species Human
Gene Type protein-coding
Description PAN2 poly(A) specific ribonuclease subunit
Other Description PAB-dependent poly(A)-specific ribonuclease subunit 2|PAB-dependent poly(A)-specific ribonuclease subunit PAN2|PAB1P-dependent poly(A)-nuclease|PABP-dependent poly(A) nuclease 2|PAN deadenylation complex catalytic subunit 2|PAN2 poly(A) specific ribonuclease subunit homolog|PAN2 polyA specific ribonuclease subunit|inactive ubiquitin carboxyl-terminal hydrolase 52|ubiquitin specific peptidase 52|ubiquitin specific protease 52
Swissprots Q76E12 O75189 Q504Q3 Q8IVE1
Accessions EAW96928 EAW96929 EAW96930 EAW96931 EAW96932 Q504Q3 AB014610 BAA31685 AB107585 BAD02263 AK001232 BAG50873 AK096679 AK310822 BC024043 AAH24043 BC094885 AAH94885 BX648106 DB290197 DB458902 NM_001127460 NP_001120932 NM_001166279 NP_001159751 NM_014871 NP_055686
Function Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618}.
Subcellular Location Cytoplasm, P-body. Nucleus. Note=Shuttles between nucleus and cytoplasm.
Top Pathways RNA degradation

PAN2 - MBS1272582 from MyBioSource

Species Human
Accession BC024043

Human PAN2 cDNA clone(NM_001166279.1) - CDFH013664 from Creative Biomart

Species Human
Accession NM_001166279.1

Human PAN2 ORF Clone(NM_001166279.1) - CDCR355275 from Creative Biomart

Species Human
Accession NM_001166279.1

Human PAN2 ORF Clone(NM_001166279.1) - CDCR355279 from Creative Biomart

Species Human
Accession NM_001166279.1

Human PAN2 Gene cDNA Clone (full-length ORF Clone) - HG13869-G from Sino Biological

Species Human
Accession BC024043

Mouse PAN2 ORF clone (NM_001166279.1) - CDCL145753 from Creative biogene

Species Human

Human PAN2 ORF Clone (BC024043) - CDCS407806 from Creative biogene

Species Human
Accession Q504Q3

Human PAN2 cDNA Clone(NM_001166279.1) - CDFH013664 from Creative biogene

Species Human
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