| Gene Symbol | Dlc1 |
|---|---|
| Entrez Gene | 50768 |
| Alt Symbol | A730069N07Rik, Arhgap7, HP, STARD12, dlc-1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | deleted in liver cancer 1 |
| Other Description | START domain-containing protein 12|p122-RhoGAP|rho GTPase-activating protein 7|rho-type GTPase-activating protein 7|stAR-related lipid transfer protein 12 |
| Swissprots | Q8R541 Q3TRX3 Q3UH75 Q9R0Z9 |
| Accessions | AAL87620 EDL35481 Q9R0Z9 AF178078 AAD51760 AK040846 AK043205 BAC31491 AK045326 BAC32310 AK053142 BAC35281 AK079114 AK086364 AK141828 AK147539 BAE27982 AK160715 AK162413 BAE36903 AK166175 BC028562 BC048730 BC056230 BC096052 BC150802 AAI50803 BE199599 GU169068 ACZ34175 GU169069 ACZ34176 GU169070 ACZ34177 HM008381 ADE60006 XM_006509166 XP_006509229 XM_006509167 XP_006509230 XM_006509168 XP_006509231 XM_006509169 XP_006509232 XM_011242151 XP_011240453 XM_011242152 XP_011240454 XM_011242153 XP_011240455 NM_178735 NM_001194940 NP_001181869 NM_001194941 NP_001181870 NM_015802 NP_056617 |
| Function | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery. {ECO:0000250}. |
| Tissue Specificity | Widely expressed with the highest levels in heart, liver and lung. |