AKT2
| Gene Symbol | AKT2 |
|---|---|
| Entrez Gene | 208 |
| Alt Symbol | HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA |
| Species | Human |
| Gene Type | protein-coding |
| Description | v-akt murine thymoma viral oncogene homolog 2 |
| Other Description | PKB beta|RAC-PK-beta|RAC-beta serine/threonine-protein kinase|murine thymoma viral (v-akt) homolog-2|protein kinase Akt-2|protein kinase B beta|rac protein kinase beta |
| Swissprots | P31751 Q68GC0 Q0VAN1 Q0VAN0 Q05BV0 B2RBD8 |
| Accessions | AAT97984 EAW56941 EAW56942 EAW56943 P31751 AK054771 AK055779 BAG51573 AK122839 AK294453 BAG57690 AK304209 BAH14135 AK308006 AK308906 AK314619 BAG37185 BC022779 AAH22779 BC032709 AAH32709 BC040028 BC063421 AAH63421 BC120994 AAI20995 BC120995 AAI20996 BM675176 BQ219902 CN351354 M77198 AAA36585 M95936 AAA58364 XM_011526614 XP_011524916 XM_011526615 XP_011524917 XM_011526616 XP_011524918 XM_011526617 XP_011524919 XM_011526618 XP_011524920 XM_011526619 XP_011524921 XM_011526620 XP_011524922 XM_011526621 XP_011524923 XM_011526622 XP_011524924 NM_001243027 NP_001229956 NM_001243028 NP_001229957 NM_001626 NP_001617 |
| Function | AKT2 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glyco |
| Subcellular Location | Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. |
| Tissue Specificity | Expressed in all cell types so far analyzed. |
| Top Pathways | Apoptosis, Tight junction, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway |
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