| Gene Symbol |
EIF4A1
|
| Entrez Gene |
1973
|
| Alt Symbol |
DDX2A, EIF-4A, EIF4A, eIF-4A-I, eIF4A-I
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 4A1
|
| Other Description |
ATP-dependent RNA helicase eIF4A-1|eukaryotic initiation factor 4A-I|eukaryotic initiation factor 4AI|eukaryotic translation initiation factor 4A
|
| Swissprots |
J3QLC4 D3DTP9 P60842 B2R6L8 Q5U018
|
| Accessions |
AAF34151 EAW90166 EAW90167 EAW90168 EAW90169 P60842 AA446856 AK130082 AK289453 BAF82142 AK291971 BAF84660 AK296664 BAG59261 AK297916 BAG60234 AK303222 BAG64309 AK303599 BAG64614 AK309274 AK312630 BAG35515 BC006210 BC009585 AAH09585 BC032078 BC073752 AAH73752 BG284868 BT019880 AAV38683 BT019881 AAV38684 D13748 BAA02897 DQ893044 ABM83970 DQ896288 ABM87287 U79273 NM_001204510 NP_001191439 NM_001416 NP_001407
|
| Function |
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.
|
| Top Pathways |
RNA transport
|
![Western Blot: eIF4A1 Overexpression Lysate (Adult Normal) [NBL1-10201] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for eIF4A1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1709_eIF4A1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10201-img0002.jpg)