GTF2I

Gene Symbol	GTF2I
Entrez Gene	2969
Alt Symbol	BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6
Species	Human
Gene Type	protein-coding
Description	general transcription factor IIi
Other Description	BTK-associated protein, 135kD|Bruton tyrosine kinase-associated protein 135|SRF-Phox1-interacting protein|Williams-Beuren syndrome chromosome region 6|general transcription factor II-I
Swissprots	Q75M88 Q75M85 Q75M87 Q75M86 O15359 Q9BSZ4 Q86U51 O14743 O43588 O43546 P78347 O43589
Accessions	AAL93085 AAS07460 AAS07461 AAS07462 AAS07463 AAS07464 EAW69594 EAW69595 EAW69596 EAW69597 EAW69598 P78347 AA641906 AF015553 AAB70791 AF035737 AAC08312 AF038967 AAC08313 AF038968 AAC08314 AF038969 AAC08315 AK057670 AK093663 AK096095 AK292832 BAF85521 AK294935 BAG58013 AK297238 BAG59719 BC004472 AAH04472 BC070484 AAH70484 BC099907 AAH99907 BT007450 AAP36118 CB118501 DC346283 KJ534859 AHW56499 KJ534860 AHW56500 KJ534861 AHW56501 KJ534862 AHW56502 KJ534863 AHW56503 KJ534965 AHW56605 U77948 AAB48826 Y14946 CAA75163 XM_011516110 XP_011514412 XR_927460 NM_001163636 NP_001157108 NM_001280800 NP_001267729 NM_001518 NP_001509 NM_032999 NP_127492 NM_033000 NP_127493 NM_033001 NP_127494
Function	Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10373551}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00484, ECO:0000269|PubMed:10373551}. Note=Colocalizes with BTK in the cytoplasm.
Tissue Specificity	Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues.
Top Pathways	Herpes simplex infection, cGMP-PKG signaling pathway, Basal transcription factors

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TFII I full length protein - ab114787 from Abcam Category Protein Source Wheat germ Species Human

Human TFII I full length protein - ab152444 from Abcam Category Protein Source Wheat germ Species Human

Human TFII I protein fragment - ab114786 from Abcam Category Protein Source Wheat germ Species Human

GTF2I / TFII I Antibody Blocking Peptide - LS-E5592 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GTF2I / TFII I Antibody Blocking Peptide - LS-E11133 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GTF2I / TFII I Antibody Blocking Peptide - LS-E21219 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GTF2I / TFII I Antibody Blocking Peptide - LS-E8523 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TFII-I Recombinant Protein - H00002969-P03 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human TFII-I Protein - H00002969-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human TFII-I Protein - H00002969-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GTF2I-Antibody-N-term-Blocking-Peptide - BP18119a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GTF2I-Antibody-C-term-Blocking-Peptide - BP6881b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GTF2I / TFII-I - H00002969-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

GTF2I / TFII-I - H00002969-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

GTF2I / TFII-I - H00002969-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

GTF2I / TFII-I - H00002969-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

GTF2I / TFII-I - H00002969-P03 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

GTF2I fusion protein - Ag0773 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human GTF2I - GTF2I-29513TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human GTF2I - GTF2I-29514TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human GTF2I, GST-tagged - GTF2I-13601H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Elastin (ELN) - RPB337Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human General transcription factor II-I(GTF2I) ,partial - CSB-YP010015HU CSB-EP010015HU CSB-BP010015HU CSB-MP010015HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

GTF2I Peptide - abx164840 from Abbexa Category Peptide Species Human, Mouse, Rat

KLH Conjugated Elastin (ELN) - CPB337Hu31 from Cloud-clone Category Protein Source n/a Species Human

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