MAP3K5

Gene Symbol MAP3K5
Entrez Gene 4217
Alt Symbol ASK1, MAPKKK5, MEKK5
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase 5
Other Description ASK-1|MAP/ERK kinase kinase 5|MAPK/ERK kinase kinase 5|MEK kinase 5|MEKK 5|apoptosis signal regulating kinase 1|apoptosis signal-regulating kinase 1
Swissprots B4DGB2 Q5THN3 Q99683 A6NIA0 Q99461
Accessions AAT52164 EAW47942 Q99683 AB209093 BAD92330 AK293953 BAG57328 AK294507 BAG57723 AK310942 BC054503 AAH54503 BC088829 AAH88829 D84476 BAA12684 U67156 AAC50894 XM_011535837 XP_011534139 XM_011535838 XP_011534140 XM_011535839 XP_011534141 NM_005923 NP_005914
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7
Subcellular Location Cytoplasm. Endoplasmic reticulum. Note=Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.
Tissue Specificity Abundantly expressed in heart and pancreas.
Top Pathways Amyotrophic lateral sclerosis (ALS), MAPK signaling pathway, Neurotrophin signaling pathway, Protein processing in endoplasmic reticulum, TNF signaling pathway

MAP3K5 293T Cell Transient Overexpression Lysate(Denatured) - H00004217-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

MAP3K5 HEK293 Cell Transient Overexpression Lysate (Non-Denatured) - L141T6 from Acris Antibodies

Category Cell Lysate
Prices $290.00
Sizes 100 µg

MAP3K5 293 Cell Lysate - 401601 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

ASK1 Overexpression Lysate (Denatured) - H00004217-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Lane 1: MAP3K5 transfected lysate (151.25 KDa) Lane 2: Non-transfected lysate.

ASK1 Overexpression Lysate (Native) - NBL1-12856 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: ASK1 Overexpression Lysate (Adult Normal) [NBL1-12856] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ASK1.

ASK 1 (h2): 293T Lysate - sc-116417 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

MAP3K5 Over-expression Lysate Product - GWB-839B76 from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Panoply™ Human MAP3K5 Knockdown Stable Cell Line - CSC-DC009175 from Creative biogene

Category Cell Line
Species Human
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