Gene Symbol PRKAA2
Entrez Gene 5563
Species Human
Gene Type protein-coding
Description protein kinase, AMP-activated, alpha 2 catalytic subunit
Other Description 5'-AMP-activated protein kinase catalytic subunit alpha-2|5'-AMP-activated protein kinase, catalytic alpha-2 chain|ACACA kinase|AMP-activated protein kinase alpha-2 subunit variant 2|AMP-activated protein kinase alpha-2 subunit variant 3|AMPK alpha 2|AMPK subunit alpha-2|AMPK-alpha-2 chain|HMGCR kinase|acetyl-CoA carboxylase kinase|hydroxymethylglutaryl-CoA reductase kinase
Swissprots Q9H1E8 Q9UD43 P54646
Accessions AAB32732 EAX06650 P54646 AI732856 AK314011 BAG36722 AL596521 AL710110 BC043195 BC069680 AAH69680 BC069740 AAH69740 BC069823 AAH69823 BM979925 CB985850 CF552084 DA710012 EF056019 ABK30810 FJ200485 ACO54882 FJ200486 ACO54883 HQ628625 AER93375 U06454 AAA64745 NM_006252 NP_006243
Function Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphoryl
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:15866171}. Note=In response to stress, recruited by p53/TP53 to specific promoters.
Top Pathways Glucagon signaling pathway, AMPK signaling pathway, Oxytocin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), PI3K-Akt signaling pathway

Human PRKAA2 gene - orb90979 from Biorbyt

Prices $255.00
Sizes 10 μg
Species Human

Human-PRKAA2-cDNA-Clone - DC08821 from Abgent, a WuXi AppTec company

Prices $745.20
Sizes 10 µg
Species Human
Accession BC069680

Human PRKAA2 ORF clone(NM_006252.3) - CDCL185814 from Creative Biomart

Species Human
Accession NM_006252.3

Human PRKAA2 ORF clone(NM_006252.3) - CDCL185814 from Creative biogene

Species Human

Human PRKAA2 ORF Clone (BC069680) - CDCS412626 from Creative biogene

Species Human
Accession P54646
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