PRKCA

Gene Symbol	PRKCA
Entrez Gene	5578
Alt Symbol	AAG6, PKC-alpha, PKCA, PRKACA
Species	Human
Gene Type	protein-coding
Description	protein kinase C, alpha
Other Description	PKC-A|aging-associated gene 6|protein kinase C alpha type
Swissprots	Q96RE4 P17252 B5BU22 Q15137 Q32M72
Accessions	AAK84184 ABY87554 AGC09604 CAJ00128 CAV30668 EAW89014 P17252 AA017296 AB209475 BAD92712 AB451258 BAG70072 AB451383 BAG70197 AF035594 AF035595 AF086287 AK055431 AK125425 AK130736 AL596674 AY633609 AAV33302 BC015855 BC053321 AAH53321 BC062759 BC071767 BC103691 BC107592 BC109273 AAI09274 BC109274 AAI09275 BC122530 BM015483 BQ018414 BU150006 BX648954 CA417000 EU832768 ACE87779 GQ129311 ACT64445 M22199 AAA60098 X52479 CAA36718 XM_011524989 XP_011523291 XM_011524990 XP_011523292 XM_011524991 XP_011523293 XM_011524992 XP_011523294 NM_002737 NP_002728
Function	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppr
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Nucleus.
Top Pathways	Wnt signaling pathway, Tight junction, VEGF signaling pathway, Focal adhesion, Gap junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PKCA gene - orb90648 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-PRKCA-cDNA-Clone - DC09569 from Abgent, a WuXi AppTec company Prices $907.20 Sizes 10 µg Species Human Accession BC109273

PRKCA - MBS1271168 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC109273

Human PRKCA cDNA clone(NM_002737.2) - CDFH015116 from Creative Biomart Species Human Accession NM_002737.2

Human PRKCA ORF Clone(NM_002737.2) - CDCR283929 from Creative Biomart Species Human Accession NM_002737.2

Human PRKCA ORF Clone(NM_002737.2) - CDCR283930 from Creative Biomart Species Human Accession NM_002737.2

Human PKCA/PRKCA Gene ORF cDNA clone in cloning vector - HG10026-M from Sino Biological Species Human

Human PKCA/PRKCA Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10026-ACG from Sino Biological Species Human

Human PKCA/PRKCA Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10026-NF from Sino Biological Species Human

Human PKCA/PRKCA Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10026-CF from Sino Biological Species Human

Human PKCA/PRKCA Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10026-NM from Sino Biological Species Human

Human PKCA/PRKCA Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10026-CM from Sino Biological Species Human

Human protein kinase C, alpha Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10026-M-F from Sino Biological Species Human Accession NM_002737.2

Human PKCA/PRKCA Gene ORF cDNA clone expression plasmid, N-His tag - HG10026-NH from Sino Biological Species Human

Human PKCA/PRKCA Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10026-ACR from Sino Biological Species Human

Human PKCA/PRKCA Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10026-ANR from Sino Biological Species Human

Human PKCA/PRKCA Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10026-ANG from Sino Biological Species Human

Human PKCA/PRKCA Gene ORF cDNA clone expression plasmid, C-HA tag - HG10026-CY from Sino Biological Species Human

Human PKCA/PRKCA Gene ORF cDNA clone expression plasmid, C-His tag - HG10026-CH from Sino Biological Species Human

Human PKCA/PRKCA Gene ORF cDNA clone expression plasmid - HG10026-UT from Sino Biological Species Human

Human PKCA/PRKCA Gene ORF cDNA clone expression plasmid, N-HA tag - HG10026-NY from Sino Biological Species Human

Human protein kinase C, alpha ORF clone(NM_002737.2) - CDCL185864 from Creative biogene Species Human

Human PRKCA ORF Clone (BC109273) - CDCS410929 from Creative biogene Species Human Accession P17252

Human PRKACA gene - orb92236 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human PRKCA cDNA Clone(NM_002737.2) - CDFH015116 from Creative biogene Species Human

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