| Gene Symbol | CAV3 |
|---|---|
| Entrez Gene | 859 |
| Alt Symbol | LGMD1C, LQT9, VIP-21, VIP21 |
| Species | Human |
| Gene Type | protein-coding |
| Description | caveolin 3 |
| Other Description | M-caveolin|caveolin-3 |
| Swissprots | Q3T1A4 A8K777 P56539 |
| Accessions | AAC39758 AAG02025 EAW63945 EAW63946 P56539 AA993189 AF036365 AAC39756 AF043101 AAC14931 AK291892 BAF84581 BC069368 AAH69368 BC102033 AAI02034 BC102036 AAI02037 BC102037 AAI02038 BF310794 BX114193 Y14747 CAA75042 NM_001234 NP_001225 NM_033337 NP_203123 |
| Function | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed predominantly in muscle. {ECO:0000269|PubMed:9545514}. |
| Top Pathways | Focal adhesion, Endocytosis, Bacterial invasion of epithelial cells, Proteoglycans in cancer |